Endothelial progenitors promote hepatocarcinoma intrahepatic metastasis through monocyte chemotactic protein-1 induction of microRNA-21

Conclusions
Our results provide new insights into the complexity of EPC-HCC interactions and indicate that anticancer therapies targeting either the MCP-1 released from angiogenic EPCs or the miR-21 biogenesis in HCC cells may prevent the malignant progression of primary tumours.

Source: Gut - June 9, 2015 Category: Gastroenterology Authors: Shih, Y.-T., Wang, M.-C., Zhou, J., Peng, H.-H., Lee, D.-Y., Chiu, J.-J. Tags: Hepatic cancer Hepatology Source Type: research