People with Type 2 Diabetes on Premixed Insulin Therapy: How is the Daily Insulin Dose Partitioned and are there Effects on the Metabolic Control?

Conclusion: The quite common recommendation in German and Austrian medical textbooks, that premixed insulin therapy should consists of a dose distribution with two thirds before breakfast and one third before dinner, is not observed in daily practice. Diurnal insulin dose distribution and HbA1c are not associated in this cohort.
Novelty statement: The circadian insulin dose distribution of 2/3 before breakfast and 1/3 before dinner could not be confirmed for patients with diabetes type 2 and conventional insulin therapy. No correlation between metabolic control and insulin circadian insulin dose distribution was detected.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text

Source: Experimental and Clinical Endocrinology and Diabetes - June 9, 2015 Category: Endocrinology Authors: Roth, J.Milke, B.Müller, N.Zitterbart, U.Rechtacek, S.Rechtacek, T.Kloos, C.Wolf, G.Müller, U. A. Tags: Article Source Type: research