Consider combining therapies for atopic dermatitis
Cyclosporine and oral antihistamine therapy showed inconsistent effects on clinical and laboratory markers of atopic dermatitis in older children and adults, based on data from a study of 48 patients. A total of 25 patients aged 16-42 years received oral cyclosporine and 23 patients aged 15-32...googletag.display('div-gpt-ad-cta');
Conclusions: Keeping a dog at home before and during pregnancy decreased the risk of food allergy in 1-year-old children. This effect was eliminated in case of having a cat, hamster, guinea pig, or rabbit. PMID: 32489363 [PubMed]
Emergency providers expeditiously sift and sort patients on their shifts and streamline procedures like how to place an ear wick in a patient with otitis externa, a quick and useful procedure for a patient who will reap the rewards.Standard ear wicks. The material is made from a dehydrated sponge composed of hydroxylated poly(vinyl acetate). It increases in size when liquid is applied. Photo by M. Roberts.Otitis externa can cause significant swelling, irritation, pruritis, and pain to the ear canal. Occasionally, the canal is so swollen it may be difficult to administer ear drops. An ear wick can be inserted between the...
Publication date: June 2020Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 8, Issue 6Author(s): Eun Lee, So-Yeon Lee, Hwan-Cheol Kim, Kil Yong Choi, Hyo-Bin Kim, Min Jee Park, Eun-Sang Rhee, Ji-Sun Yoon, Hyun-Ju Cho, Sungsu Jung, Kangmo Ahn, Kyung Won Kim, Youn Ho Sheen, Dong In Suh, Soo-Jong Hong
Publication date: June 2020Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 8, Issue 6Author(s):
Publication date: June 2020Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 8, Issue 6Author(s): Takashi Nomura, Jianni Wu, Kenji Kabashima, Emma Guttman-Yassky
Are those with atopic dermatitis more likely to develop food allergies?Current Opinion in Allergy and Clinical Immunology
CONCLUSION: Advances in our understanding of the neuroimmunology of chronic pruritus has led to the identification of new therapeutic targets and the rapid development of cutting-edge clinical trials. Although incredible advances have already been made, chronic itch continues to be an area of great unmet need. PMID: 32497711 [PubMed - as supplied by publisher]
ConclusionsSensitization to skin resident fungi includingMalassezia globosa is uncommon in European CholU patients, but is associated with atopy and pronounced wheal formation upon dermal contact with their own sweat.Trial registration German Clinical Trials Registry DRKS-ID: DRKS00004277
The fundamental defect(s) that drives atopic dermatitis (AD) remains controversial. “Outside in” proponents point to the important association of filaggrin gene mutations and other skin barrier defects with AD. The “inside out” proponents derive support from evidence that AD occurs in genetic animal models with overexpression of type 2 immune pathways in their skin, and hum ans with gain-of-function mutations in their type 2 response develop severe AD. The observation that therapeutic biologics, targeting type 2 immune responses, can reverse AD provides compelling support for the importance of &ldqu...
Chronic pruritus, or itch lasting>6 weeks, is a common symptom and has a profoundly negative impact on quality of life. While many primary dermatologic disorders such as atopic dermatitis and chronic urticaria are characterized by pruritus, numerous other allergic, hepatobiliary, lymphoproliferative, neurologic, and renal disorders are associated with chronic pruritus. Itch involves complex interactions orchestrated by a variety of factors released from and acting on the skin, immune system, and the sensory nervous system.