Ultrasound and algorithms to diagnose bacterial meningitis in babies

(FECYT - Spanish Foundation for Science and Technology) Currently the only test to diagnose bacterial meningitis in babies is through a lumbar puncture, a painful and difficult procedure to perform. For this reason, a group of biomedical engineers decided to search for an alternative and developed a portable device that can detect this illness with a simple ultrasound scan of the fontanelle. The high-resolution image obtained is then analyzed with algorithms and within seconds indicates if there is cellularity in the cerebrospinal fluid that is sign of infection.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Publication date: Available online 10 June 2019Source: Clinica Chimica ActaAuthor(s): Elena Aloisio, Alberto Dolci, Mauro PanteghiniAbstractSepsis is a life-threatening organ dysfunction caused by a dysregulated response of the host to infection. It represents one of the major health care problems worldwide. Unfortunately, the diagnosis of sepsis is challenging for many reasons, including a lack of a sufficiently sensitive and specific diagnostic test. When procalcitonin (PCT) was discovered, it was thought that it could become the best test for identifying patients with sepsis. From the evidence sources in the available l...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Authors: Rouviere D, Veillon R, Chaltiel L, Simonneau Y, Filleron T, Milia J, Guibert N, Melloni B, Raherisson C, Didier A, Mazieres J Abstract The central nervous system (CNS), through carcinomatous meningitis or solid brain metastases, is the most common site of recurrence in non-small cell lung cancers (NSCLC) with activating mutations. Our retrospective study describes the population of patients with CNS metastases of NSCLC harboring activating mutation with targeted therapy (EGFR, ALK, BRAF, HER2) in 4 French regional reference hospitals. 60 patients were analyzed. The proposed treatments were heterogeneous an...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
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Source: Parasitology International - Category: Parasitology Source Type: research
Authors: Vassalini P, Ajassa C, Di Ruscio V, Morace A, Vergari J, Tosato C, Savelloni G, Mastroianni CM Abstract Drug-induced aseptic meningitis (DIAM) represents a diagnostic challenge since clinical and cerebrospinal fluid (CSF) findings may be indistinguishable from a bacterial meningitis. Intravenous immunoglobulin (IVIg) are commonly used in a variety of diseases, including inflammatory and autoimmune disorders. Although usually well-tolerated, various adverse effects have been reported. DIAM is a serious neurological side effect of IVIg therapy: albeit rare (0.067% of all IVIg infusions), the condition repres...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Authors: Leli C, Di Matteo L, Gotta F, Vay D, Calcagno L, Callegari T, Cassinari M, Cattana E, Ciriello MM, Copponi V, Sacchi MC, Zambon D, Guaschino R, Rocchetti A Abstract Infectious meningitis and encephalitis are potentially life-threatening conditions caused mostly by bacterial and viral agents. Rapid diagnosis and prompt treatment are associated with a more favorable outcome. In recent years nucleic acid amplification tests have been developed to speed detection and identification of pathogens directly from cerebrospinal fluid (CSF). The aim of this study was to compare the diagnostic accuracy of a commercial...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
We report that all 15 test systems were consistent in that they showed sample A to be the most active in the MAT; that 13 of 15 test systems had an accuracy of more than 80% and an overall geometric mean RPU of 1.03 with lower and upper 95% confidence limits of 0.97 and 1.09 respectively for a sample with an expected value of 1.00 RPU. We also report larger variability in the results for test systems involving cells from individual blood donations for sample A suggesting that there could be donor to donor differences in sensitivity to the vaccine constituents responsible for the higher activity of this batch. Overall, the ...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Abstract It is imperative to ensure biological products are free of contaminating pyrogenic material prior to administration to patients. Historically the rabbit pyrogen test (RPT) was used to screen for such contamination in medicines for intravenous delivery. This test was adapted for use to screen vaccines. However, some, including meningococcal vaccines containing outer membrane vesicles, are intrinsically pyrogenic. Indeed, this is the case for Bexsero which contains relatively high levels of endotoxin and other potential pyrogens such as lipoproteins and porins. The RPT proved a difficult method for measurin...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
AbstractProperdin is known as the only positive regulator of the complement system. Properdin promotes the activity of this defense system by stabilizing its key enzymatic complexes: the complement alternative pathway (AP) convertases. Besides, some studies have indicated a role for properdin as an initiator of complement activity. Though the AP is a powerful activation route of the complement system, it is also involved in a wide variety of autoimmune and inflammatory diseases, many of which affect the kidneys. The role of properdin in regulating complement in health and disease has not received as much appraisal as the m...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Sudipta Mohakud, Nerbadyswari Deep, Suprava NaikJournal of Pediatric Neurosciences 2019 14(1):57-58
Source: Journal of Pediatric Neurosciences - Category: Neuroscience Authors: Source Type: research
Publication date: Available online 15 June 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Renat AdelshinAbstractTick-borne encephalitis virus (TBEV) can cause severe meningitis, encephalitis, and meningoencephalitis. TBEV represents a pathogen of high zoonotic potential and an emerging global threat. There are three known subtypes of TBEV: Far-Eastern, Siberian and European. Since 2001 there have been suggestions that two new subtypes may be distinguished: “178-79” and “886-84”. These assumptions are based on the results of the envelope gene fragment sequencing (Zlobin et al., 2001; Kovalev and...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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