The association of tumor volume with mortality following radical prostatectomy

The association of tumor volume with mortality following radical prostatectomy Prostate Cancer and Prostatic Diseases advance online publication, January 28 2014. doi:10.1038/pcan.2013.61 Authors: J J Knoedler, R J Karnes, R H Thompson, L J Rangel, E J Bergstralh &S A Boorjian
Source: Prostate Cancer and Prostatic Diseases - Category: Urology & Nephrology Authors: Tags: tumor volume radical prostatectomy mortality risk stratification Source Type: research

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Condition:   Prostate Cancer Intervention:   Procedure: lymph node dissection Sponsor:   Martini-Klinik am UKE GmbH Recruiting
Source: - Category: Research Source Type: clinical trials
url Klocker Heidegger Evidence has accumulated asserting the importance of cullin-RING (really interesting new gene) ubiquitin ligases (CRLs) and their regulator Cullin-associated neural-precursor-cell-expressed developmentally down-regulated 8 (NEDD8) dissociated protein 1 (Cand1) in various cancer entities. However, the role of Cand1 in prostate cancer (PCa) has not been intensively investigated so far. Thus, in the present study, we aimed to assess the relevance of Cand1 in the clinical and preclinical setting. Immunohistochemical analyses of radical prostatectomy specimens of PCa patients showed that Cand1 pr...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Nature Reviews Urology, Published online: 12 February 2020; doi:10.1038/s41585-020-0290-3No clear consensus exists for managing biochemically recurrent prostate cancer after prostatectomy. Interpretation of new data from the JCOG0401 trial warrants consideration of imaging techniques, prostate-specific antigen (PSA) levels at time of salvage radiotherapy (SRT), use of SRT ± salvage androgen deprivation therapy based on PSA levels, and the interval to biochemical failure.
Source: Nature Reviews Urology - Category: Urology & Nephrology Authors: Source Type: research
Abstract For patients experiencing biochemical recurrence in the absence of distant metastasis, salvage radiotherapy (SRT) with or without androgen deprivation therapy (ADT) is currently the only possible curative treatment option. Prostate-specific antigen (PSA) monitoring and the selected use of SRT has some advantages when compared with adjuvant radiotherapy. The most important one is avoidance of a potential overtreatment of patients who would never have disease progression, even in the presence of high-risk pathological features. The identification of a specific PSA cut-off seems to be incorrect. In patients ...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Clin Oncol (R Coll Radiol) Source Type: research
The aim of this study was to compare the cost-effectiveness and quality-adjusted life years (QALYs) of active monitoring (AM), radical prostatectomy (PR), and external-beam radiotherapy with neoadjuvant hormone therapy (RT) for localized prostate cancer. Microsimulations of radical prostatectomy, 3D-conformal radiotherapy, or active monitoring were performed using Medicare reimbursement schedules and clinical trial results for a target population of men aged 50–69 years with newly diagnosed localized prostate cancer (T1-T2, NX, M0) over a time horizon of 10 years. Quality-adjusted life years (QALYs) and costs were as...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Prostate Cancer;   Metastasis;   Prostatectomy Intervention:   Drug: Ferrotran® (Ferumoxtran-10) Sponsors:   Saving Patients' Lives Medical B.V.;   ABX-CRO advanced pharmaceutical services Forschungsgesellschaft m.b.H.;   b.e.imaging GmbH;   Radboud University Recruiting
Source: - Category: Research Source Type: clinical trials
Conclusions: mpMRI can provide additional information for the detection of prostate cancer before saturation biopsies.Level of Evidence: III. PMID: 32026731 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
ConclusionUrethrovesical anastomotic leaks are commonly seen after radical prostatectomy. Although most cases are self-limited; others can be managed by various minimally-invasive procedures, diverting urine away from the anastomosis, giving it a chance to properly heal.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
This study identifies the PSA and PSA kinetics threshold levels for the presence of 68Ga-PSMA-11 PET/CT-detectable PC-lesions in BC patients.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
We present the case of a 69-year-old man with history of prostate carcinoma treated with prostatectomy and subsequently with external beam radiotherapy and hormone therapy because of biochemical recurrences. More than 10 years after the diagnosis, follow-up 99mTc-HDP bone scans and SPECT/CT images demonstrated an incidental diagnosis of osteoblastic pleural plaques that quickly evolve to mesothelioma. PET/CT achieved the definitive diagnosis by guiding the biopsy to the highest and most accessible focus of glucidic hypermetabolism. Our case report raises the association between prostate cancer patients treated with externa...
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
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