Preferential expansion of pro-inflammatory Tregs in human non-small cell lung cancer

Conclusions This study demonstrates that a novel subset of Tregs with pro-inflammatory characteristics preferentially expand in NSCLC patients. This Treg subset appears identical to previously reported pro-inflammatory Tregs in human colon cancer patients and in mouse models of polyposis. We expect the pro-inflammatory Tregs in lung cancer to contribute to the immune pathogenesis of disease and propose that targeting this Treg subset may have protective benefits in NSCLC.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research