Perfluorooctane Sulfonate Concentrations in Amniotic Fluid, Biomarkers of Fetal Leydig Cell Function, and Cryptorchidism and Hypospadias in Danish Boys (1980-1996)

Author Affiliations open 1Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark; 2Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 3Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden; 4Department of Occupational and Environmental Medicine, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark; 5Danish Center for Neonatal Screening, Department of Clinical Biochemistry and Immunology, Statens Serum Institute, Copenhagen, Denmark; 6School of Biosciences, University of Nottingham, Nottingham, United Kingdom; 7Department of Pediatrics, Regional Hospital of Randers, Randers, Denmark; 8Perinatal Epidemiology Research Unit, Department of Pediatrics, Aarhus University Hospital, Skejby, Denmark PDF Version (331 KB) Abstract About This Article Article-Level Metrics Background: Exposure to perfluorooctane sulfonate (PFOS) may potentially disturb fetal Leydig cell hormone production and male genital development. Objectives: We aim to study the associations between amniotic fluid PFOS level and fetal steroid hormone and Insulin-like factor 3 (INSL3) level as well as the prevalence of cryptorchidism and hypospadias. Methods: Utilizing the Danish National Patient Registry, we selected 270 cryptorchidism cases, 75 hypospadias cases and 300 controls with stored maternal amniotic fluid samples available in a Danish pregnancy-screening biobank (...
Source: EHP Research - Category: Environmental Health Authors: Tags: Children's Health Source Type: research

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