Correlation Between Advanced Glycation End‐Products, Lower Urinary Tract Symptoms and Bladder Dysfunctions in Patients with type 2 Diabetes Mellitus
ObjectivesTo explore whether serum and urinary advanced glycation end‐products (AGEs) are related to urinary symptoms and bladder dysfunctions in diabetic patients. MethodsForty‐seven patients with type 2 Diabetes mellitus (T2DM) and lower urinary tract symptoms (LUTS) were enrolled. LUTS evaluation was performed by IPSS (International Prostatic Symptoms Score), QoL (quality of life), OAB (overactive bladder). ICI‐SF (International Consultation on Incontinence – short form) quaestionneires; ultrasound examination, evaluation of postvoid residual (PVR), uroflowmetry, cystometry with pressure‐flow study (PFS) were performed to detect bladder dysfunctions. Serum and urinary AGEs were quantified by ELISA method. ResultsPatients were divided into four subgroups: (i) normal‐detrusor‐contractility + normal‐ detrusor‐activity (1 ♂ [4.8%] and 4 ♀ [21%]), (ii) impaired‐detrusor‐contractility + normal‐detrusor‐ activity (4 ♂ [19.1%] and 0 ♀), (iii) normal‐detrusor‐contractility + detrusor‐overactivity (1 ♂ [4.8%] and 6 ♀ [31.6%]), (iv) impaired‐detrusor‐contractility + detrusor‐overactivity (15 ♂ [71.4%] and 9 ♀ [47.4%]). Serum AGEs were 12.2 ± 5.5 in men and 10.4 ± 5.6 in women; urinary AGEs were 1.5 ± 1.1 in men and 2.5 ± 1.6 in women. Serum AGEs exhibited a positive correlation w...
Conclusions: We found that perceived stigma in health care settings was a potential barrier to good health. Prior studies have illustrated that negative health outcomes are common for patients who avoid or delay care; thus, the unfortunate conclusion is that even in a diverse, heterogeneous community, stigma persists and may negatively affect well-being. Therefore, eliminating stigma in clinical settings should be a top priority for health care providers and public health professionals seeking to improve health equity.
[VOA] On the eve of World Diabetes Day, November 14, the World Health Organization is launching a new initiative it believes will allow greater access to life-saving insulin at lower prices for a greater number of people suffering from diabetes.
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Publication date: Available online 12 November 2019Source: Brain, Behavior, and ImmunityAuthor(s): Célia Fourrier, Camille Kropp, Agnès Aubert, Julie Sauvant, Carole Vaysse, Jean-Michel Chardigny, Sophie Layé, Corinne Joffre, Nathalie CastanonAbstractMetabolic syndrome represents a major risk factor for severe comorbidities such as cardiovascular diseases or diabetes. It is also associated with an increased prevalence of emotional and cognitive alterations that in turn aggravate the disease and related outcomes. Identifying therapeutic strategies able to improve those alterations is therefore a major s...
TYPE 2 diabetes is a serious condition which affects a person ’s blood sugar levels, and left untreated, serious health conditions can occur. Medical expert, Dr Haris Ruther offers advice on spotting the symptoms and tips on how to deal with them.
CONCLUSIONS: T2DM mice exhibited the early phase of diabetic bladder dysfunction (DBD) characterized by OAB and bladder dysfunction. SQW can improve the bladder storage and micturition of DBD mice by mediating the protein and gene expression levels of myosin Va and SLC17A9 in the bladder, instead of improving the blood glucose level.
Authors: Tanik N, Tanik S, Albayrak S, Zengin K, Inan LE, Caglayan EK, Celikbilek A, Kirboga K, Gurdal M Abstract PURPOSE: Diabetes mellitus (DM) is a chronic metabolic disorder that often leads to complications. We aimed to correlate two complications of DM, polyneuropathy and hyperactive bladder syndrome, using noninvasive measures, such as screening tests. METHODS: We included 80 female and 40 male type 2 diabetic patients in this prospective study. Diabetic polyneuropathy evaluations were conducted using the Douleur Neuropathique 4 Questions (DN4), and overactive bladder (OAB) evaluations were performed usi...
Conclusions The presence of nocturia was associated with erectile dysfunction, systemic vascular events, higher mortality, and indicated poor health in male with type 2 diabetic mellitus.
W. J. Bang, J. Y. Lee, K. C. Koo, Y. S. Hah, D. H. Lee and K. S. Cho