Acute SGLT inhibition normalizes oxygen tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats.

In conclusion, these data demonstrate that when SGLT is inhibited, renal cortex PO2 in the diabetic rat kidney is normalized, which implies that increased proximal tubule transport contributes to the development of hypoxia in the diabetic kidney. The reduction in medullary PO2 in both control and diabetic kidneys during the inhibition of proximal sodium reabsorption suggests redistribution of active sodium transport to less efficient nephron segments such as the medullary thick ascending limb which results in medullary hypoxia. PMID: 26041448 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26041448?dopt=Abstract

Source: Am J Physiol Renal P... - June 3, 2015 Category: Urology & Nephrology Authors: O Neill J, Fasching A, Pihl L, Patinha D, Franzén S, Palm F Tags: Am J Physiol Renal Physiol Source Type: research