Update on the role of Interleukin 17 in rheumatologic autoimmune diseases.

Update on the role of Interleukin 17 in rheumatologic autoimmune diseases.
Cytokine. 2015 May 28;
Authors: Konya C, Paz Z, Apostolidis SA, Tsokos GC
Abstract
Interleukin 17 is a proinflammatory cytokine produced by CD4+ T cells when in the presence of a distinct set of cytokines and other cells. Preclinical and clinical studies have assigned a role to IL-17 in tissue inflammation and damage in patients with rheumatoid arthritis, psoriasis and psoriatic arthritis, ankylosing spondylitis and systemic lupus erythematosus. Antibodies blocking the action of IL-17 have already been approved to treat patients with psoriasis and it is expected that they may also benefit patients with other rheumatic diseases.
PMID: 26028353 [PubMed - as supplied by publisher]

Source: Cytokine - May 28, 2015 Category: Molecular Biology Authors: Konya C, Paz Z, Apostolidis SA, Tsokos GC Tags: Cytokine Source Type: research