Pathogenesis of neointima formation following vascular injury.
Pathogenesis of neointima formation following vascular injury. Cardiovasc Hematol Disord Drug Targets. 2011 Mar 1;11(1):30-9 Authors: O' Brien ER, Ma X, Simard T, Pourdjabbar A, Hibbert B Abstract Revascularization remains the cornerstone of managing obstructive coronary artery disease. Although percutaneous coronary interventions involving the insertion of metal scaffolds, known as stents, has emerged as the preferred method of restoring vessel patency, as many as 30% of patients will experience a gradual re-narrowing of the lumen caused by neointima (NI) formation, resulting in a condition known as in-stent restenosis (ISR). ISR represents a significant limitation to percutaneous revascularization - however, abrogating NI formation following stent implantation has been hampered by an incomplete understanding of the pathogenesis of in-stent lesions. While numerous mechanisms have been proposed to explain the pathogenesis of ISR, data from human and animal models have yielded conflicting results. Herein, we review key studies of NI development following vascular injury with a focus on the origin of cells participating in NI formation. PMID: 21446903 [PubMed - indexed for MEDLINE]
Antioxidants&Redox Signaling, Ahead of Print.
Publication date: Available online 10 December 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): Satheesh Krishna, Ashley Leckie, Ania Kielar, Robert Hartman, Ashish KhandelwalAbstractCystic renal masses are common incidental findings on cross-sectional imaging. Accurate characterisation of cystic renal masses is essential to guide management. Renal mass protocol comprises of a good quality non-contrast, corticomedullary and nephrographic phases with each phase providing complementary information for diagnosis. Attenuation measurements in different phases are central to the ‘golden-rules’ in renal mass i...
This article reviews the risks and benefits of GBCA administration.
Publication date: Available online 10 December 2019Source: European Journal of RadiologyAuthor(s): Arun Jose, Akhil Kher, Robert E. O’Donnell, Jean M. ElwingAbstractPurposeTargeted treatment for pulmonary arterial hypertension (PAH), diagnosed via right heart catheterization (RHC), has been shown to improve morbidity and mortality. Identifying characteristics that predict clinical worsening has been challenging. We sought to evaluate the role of cardiac Magnetic Resonance Imaging (CMR) as a predictor of clinical worsening in a cohort of treatment-naïve pulmonary hypertension (PH) patients.MethodsWe performed a r...
Events: Conference Call Bayer 2030 Sustainable Development ObjectivesLive today at approx. 2:00 p.m. CET (1:00 p.m. UTC): Investor Conference Call: Bayer 2030 Sustainable Development ObjectivesLink to websiteAll changes
Bayer to significantly step-up its sustainability efforts2030 target to be carbon neutral in own operations / Ambitious 2030 objectives for access to health and nutrition in low- and middle-income countries and underserved communities / Measurable sustainability targets to be incorporated into management compensationmehr ...
to the article “Attachment Disorders,” by Gail Hornor, published in the September/October 2019 issue of the Journal (Journal of Pediatric Health Care, 33, 612–622).
This article presents a case report that illustrates how evasive the diagnosis of pericardial effusion can be. The early symptoms of pericardial effusion resemble common viral conditions that can easily be overlooked. Subtle presenting symptoms and the importance of urgent multidisciplinary collaboration and emergent referral for the child with pericarditis are summarized.
This article provides an overview of CALMs, followed by a summary of several conditions associated with CALMs ranging from the most common (neurofibromatosis type 1) to rare, ring chromosome syndromes.