Ox-LDL Particles: Modified components, Cellular uptake, Biological roles and Clinical assessments.

Ox-LDL Particles: Modified components, Cellular uptake, Biological roles and Clinical assessments.
Cardiovasc Hematol Disord Drug Targets. 2011 Oct 26;
Authors: Najafi M, Roustazadeh A, Alipoor B
Abstract
Among concepts proposed to elucidate atherosclerosis process, the oxidative modification hypothesis is more considered to be investigated in studies. Based on the hypothesis, the LDL components are chemically modified due to oxidative stress within subendothelial space of vessels. The cells are able to recognize the oxidized LDL (ox-LDL) preparations so that inflammatory events spread through intracellular pathways and lead to the cellular dysfunction and the production of atherosclerotic plaques. The circulating ox-LDL level is suggested as biomarker of atherogenic lesions. However, it is not confirmed in other studies since the circulating ox-LDL clearance during the extent of atherosclerosis process is related to function of scavenger receptors and the serum anti LDL levels. The report is focused on the biochemical characteristics of modified LDL components, the cellular internalization of ox-LDL particles through the scavenger receptors, prediction of consensus blocks in the receptor sequences and the circulating ox-LDL assessments in cardiovascular complications.
PMID: 22044040 [PubMed - as supplied by publisher]

Source: Cardiovascular and Hematological Disorders Drug Targets - June 4, 2015 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research