Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice

Conclusions: Cardiospecific CD36 inhibition protects against the aggravation of cardiac functional and morphological changes associated with HFD induced obesity. CD36 represents a potential therapeutic target for obesity cardiomyopathy.

http://www.cardiab.com/content/14/1/69

Source: Cardiovascular Diabetology - June 3, 2015 Category: Cardiology Authors: Yijie ZhangMingwei BaoMingyan DaiXin WangWenbo HeTuantuan TanDandan LinWei WangYing WenRui Zhang Source Type: research