Common antibiotic part of a new potential pancreatic cancer therapy

A new promising combination therapy has been discovered for the treatment of one of the most deadly and difficult cancers to manage. Scientists developed a novel combination of an experimental drug and a common antibiotic that has shown encouraging results in treating pancreatic cancer in preclinical experiments.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionTFAE have anti-tumor activity against pancreatic cancer and can induce apoptosis and autophagy through PI3K/Akt/mTOR signal pathway. TFAE might be a potential anticancer drug to be further developed for human pancreatic cancer therapy.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
DTLP showed bispecific binding activities to EGFR/HER ‐2 in vitro and in vivo. DTLL showed potent anti‐pancreatic cancer efficacy in CDX and PDX mouse models of human pancreatic cancer 3. DTLL had an antineoplastic effect by inhibited AKT/mTOR and PD‐1/PD‐L1 signal pathways in human pancreatic cancer. AbstractPancreatic ductal adenocarcinoma (PDAC) is a refractory malignant tumor with poor prognosis, limited chemotherapeutic efficacy, and only about 5% of 5 ‐year survival rate. We generated a dual‐targeting ligand‐based lidamycin (DTLL) to investigate its efficacy against pancreatic cancer after preparing its...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
This study aimed to identify the function of S100A11 associated with cell proliferation and invasion in gastric cancer. We used cell culture, western blotting, reverse transcription-polymerase chain reaction, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and S100A11 knock-down with short hairpin ribonucleic acid (shRNA). First, we confirmed that the S100A11 expression was upregulated by hepatocyte growth factor (HGF). The role of S100A11 was determined via knock down of S100A11. S100A11-shRNA cells showed decreased levels of metalloproteinase-9 (MMP9) and nuclear factor kappa-B (NF-κB). We also ...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
CONCLUSIONS: With respect to quality of life or reduction of treatment-associated side effects, a thorough review of the literature does not provide any indication to prescribe mistletoe to patients with cancer. PMID: 30673872 [PubMed - as supplied by publisher]
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: J Cancer Res Clin Oncol Source Type: research
ConclusionsWith respect to quality of life or reduction of treatment-associated side effects, a thorough review of the literature does not provide any indication to prescribe mistletoe to patients with cancer.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
tti E Abstract Noncoding RNAs play important regulatory roles in diverse biological processes and their misregulation might lead to different diseases, including cancer. Previous studies have reported the evolving role of miRNAs as new potential biomarkers in cancer diagnosis, prognosis, as well as predictive biomarkers of chemotherapy response or therapeutic targets. In this review, we outline the involvement of noncoding RNA in pancreatic cancer, providing an overview of known miRNAs in its diagnosis, prognosis and chemoresistance. In addition, we discuss the influence of non-coding RNAs in the metastatic behavi...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
In this study, hyaluronic acid (HA) conjugated bovine serum albumin (BSA) nanoparticles have been synthesized according to AmiNoAcid Decorated and Light Underpinning Conjugation Approach (ANADOLUCA) that provides microemulsion polymerization at room temperature, under a nitrogen atmosphere in daylight. The synthesized nano BSA-HA particles have been characterized by Circular Dichroism (CD), Scanning Electron Microscopy (SEM), fluorescence spectrum and thermal gravimetric analysis. Then, nano BSA-HA particles have been used in vitro cytotoxicity analysis and imaging of PANC-1 ATCC® CRL146 cells. Cytotoxic effect of nano...
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Tags: Protein Pept Lett Source Type: research
ConclusionA novel EGFR-targeting ADC, RC68-PY-VC-PAB-MMAE, shows promise as an effective, selective, and safe therapeutic agent for EGFR-positive pancreatic cancer.
Source: Targeted Oncology - Category: Cancer & Oncology Source Type: research
Pancreatic neuroendocrine neoplasm (panNEN) is a rare malignancy with relatively indolent biologic behavior compared to pancreatic adenocarcinoma [1]. Its incidence sharply increased in recent years, possibly due to a higher detection rate with the proliferation of modern imaging and endoscopic technologies [2]. Radiomics is an emerging field of investigation, with great potential in identifying associations between image-based features and biological or clinical endpoints, thus supporting the way for personalized cancer therapies [3].
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Tags: Original paper Source Type: research
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