Atmospheric Interactions and Cardiac Arrhythmias
Department of Cardiology, University Hospital Center Split, Split, Croatia About This Article open Citation: Čulić V. 2015. Atmospheric interactions and cardiac arrhythmias. Environ Health Perspect 123:A144; http://dx.doi.org/10.1289/ehp.1409636 E-mail: email@example.com The author declares he has no actual or potential competing financial interests. Final Publication: 1 June 2015 PDF Version (85 KB) Although plausible pathophysiological mechanisms link air pollution to arrhythmogenesis, among them altered autonomic tone, repolarization abnormalities, oxidative stress, myocardial ischemia, and increased intracardiac pressure (Link and Dockery 2010), definitive conclusions have not been reached as yet. Langrish et al. (2014) analyzed 13 double-blind randomized crossover studies and found no significant risk of arrhythmia attributable to acute controlled exposure to air pollutants. Three issues related to meteorological factors probably either confound or modify the short-term association between air pollution and cardiac arrhythmia. First, several meteorological elements, including air temperature, atmospheric pressure, relative air moisture, and wind speed and direction, also are implicated in triggering ventricular (Čulić et al. 2004, 2005) and supraventricular (Čulić et al. 2012, 2013) arrhythmias independent of physical and emotional stress. In the short term, those meteorological factors may facilitate arrhythmias in susceptible patients by incre...
Aberrant expression of the cardiac gap junction protein connexin-43 (Cx43) has been suggested as playing a role in the development of cardiac disease in the mdx mouse model of Duchenne muscular dystrophy (DMD); however, a mechanistic understanding of this association is lacking. Here, we identified a reduction of phosphorylation of Cx43 serines S325/S328/S330 in human and mouse DMD hearts. We hypothesized that hypophosphorylation of Cx43 serine-triplet triggers pathological Cx43 redistribution to the lateral sides of cardiomyocytes (remodeling). Therefore, we generated knockin mdx mice in which the Cx43 serine-triplet was ...
This study contributes to the understanding of pathologic Cx43 remodeling and encourages further research into developing strategic interventions to mitigate cardiac dysfunction and arrhythmias in DMD patients.
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