Serum levels of type I interferon (IFN-I) is associated with the severity of COVID-19

Conclusion. These results demonstrate that macrophages and DCs are the main origination of IFN-I, and serum levels of IFN-I are positively associated with lymphopenia and cytokine storm, suggesting that IFN-α/β deteriorated the severity of COVID-19. Anti-interferon or IFN-I signalling block drugs are needed to treat ICU patients.PMID:37526406 | DOI:10.1099/jmm.0.001694

Source: Journal of Medical Microbiology - August 1, 2023 Category: Microbiology Authors: Yuting Sun Gang Wang Rongshuai Wang Liang Ren Zilin Yuan Yueping Liu Yuzhang Wu Rong Chen Yongwen Chen Bo Diao Source Type: research