Anti-albuminuric actions of calcilytics in the remnant kidney.

Anti-albuminuric actions of calcilytics in the remnant kidney. Am J Physiol Renal Physiol. 2015 May 27;:ajprenal.00003.2015 Authors: Takenaka T, Inoue T, Miyazaki T, Nishiyama A, Ishii N, Hayashi M, Suzuki H Abstract Hyperphosphatemia accelerates the progression of chronic kidney diseases. In the present study, the effects of ronacaleret, a calcilytic agent, on renal injury were assessed in four groups of rats; 5/6-nephrectomized Wistar rats as a control (C), rats treated with ronacaleret (3 mg/kg/day) (R), rats treated with calcitriol (30 ng/kg/day) (V), and rats treated with both ronacaleret and calcitriol (R+V). Three months later, the rats were euthanized under anesthesia, and the remnant kidneys were harvested for analysis. Albuminuria was lower in R and V groups than C group (p<0.05). Creatinine clearance was elevated in R and V groups in comparison to C group (p<0.05). Serum calcium and renal angiotensin II were higher in R+V group than C group (p<0.05 for each), and serum phosphate was reduced in R group in comparison to C group (p<0.05). FGF23 was lower in R group and higher in V and R+V groups than C group. However, parathyroid hormone did not differ significantly among the 4 groups. Renal klotho expression was elevated in R and V groups in comparison to C group (p<0.05). The present data indicate that ronacaleret preserves klotho expression and renal function with reductions in serum phosphate and albuminuri...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research