Acrolein Exposure in U.S. Tobacco Smokers and Non-Tobacco Users: NHANES 2005-2006

Author Affiliations open Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA PDF Version (747 KB) Abstract About This Article Supplemental Material Article-Level Metrics Background: Acrolein is a highly reactive α, β unsaturated aldehyde and respiratory irritant. Acrolein is formed during combustion (e.g. burning tobacco or biomass), during high-temperature cooking of foods, and in vivo as a product of oxidative stress and polyamine metabolism. No biomonitoring reference data has been reported to characterize acrolein exposure of the U.S. population. Objectives: Our goals were to: a) evaluate two acrolein metabolites in urine – N-Acetyl-S-(3-hydroxypropyl)-L-cysteine (3HPMA) and N-acetyl-S-(2-carboxyethyl)-L-cysteine (CEMA) – as biomarkers of exposure to acrolein for the U.S. population by age, sex, race, and smoking status; and b) assess tobacco smoke as a predictor of acrolein exposure. Methods: We analyzed urine from National Health and Nutrition Examination Survey (NHANES 2005-2006) participants ≥ 12 years-old (n = 2,866) for 3HPMA and CEMA using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC/ESI-MSMS). Sample-weighted linear regression models stratified for non-tobacco users vs. tobacco smokers (as defined by serum cotinine and self-report) characterize...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Article Source Type: research

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