Prostate Cancer Prognostic Factors Among Asian Patients Born in the US Compared to Those Born Abroad

Abstract US surveillance data indicate that incidence of prostate cancer differs by place of birth among Asian men. However, it is less clear if the prognostic factors for prostate cancer also differ by place of birth. The study included 7,824 Asian prostate cancer patients diagnosed between 2004 and 2009 and reported to the Surveillance Epidemiology and End Results (SEER) program. Logistic regression models were used to evaluate the relation of place of birth (foreign born vs. US born) to three outcomes: prostate specific antigen (PSA) level, Gleason score, and T classification, adjusting for age, marital status, Rural–Urban Continuum Code, and SEER registry. All outcome variables were binary using different cutoffs: ≥4, ≥10 and ≥20 ng/ml for PSA; ≥7 and ≥8 for Gleason score; and ≥T2 and ≥T3 for T classification. Elevated PSA was more common among foreign born Asian men regardless of the cut point used. In the analysis comparing foreign born versus US born patients by ethnic group, the association with PSA was most pronounced at cut point of ≥20 ng/ml for Chinese men (OR 1.68, 95 % CI 1.02–2.75), and at cut point of ≥4 ng/ml for Japanese men (OR 2.73, 95 % CI 1.20–6.21). A statistically significant association with Gleason score was only found for Japanese men and only for the cutoff ≥7 (OR 1.71, 95 % CI 1.12–2.61). There was no difference in clinical T classification between foreign-born and US-born Asian men. Inclusion ...
Source: Journal of Immigrant and Minority Health - Category: Global & Universal Source Type: research