Q&A: Dr. John Mazziotta on the future of UCLA’s medical school and health system

Earlier in his life, Dr. John C. Mazziotta thought about becoming an architect. With a keen eye for form and function, he would apply his skills to the construction of great buildings. Instead, he chose medicine. Now, after more than 30 years at UCLA — where he has been chair of the department of neurology, an associate vice chancellor and executive vice dean, and founding director of the Ahmanson-Lovelace Brain Mapping Center — that style of visual thinking will serve him well in his new roles as vice chancellor for UCLA Health Sciences, dean of the David Geffen School of Medicine at UCLA and CEO of UCLA Health. “There are many parallels between architecture and construction and what we do in medicine and the building of a large medical enterprise,” he said. “And, on a purely administrative level, it doesn’t hurt to have some interest in the subject when you are managing millions of square feet of space and renovating a giant building. Having some interest and experience about how these things work is helpful.” Mazziotta spoke with U Magazine editor David Greenwald about his new roles and his aspirations for the future of the medical school and health system. As vice chancellor, dean and CEO, you bridge the worlds of the health system and the medical school. How does each of these worlds inform the other? We have one health organization with two big pieces to it: the health system — the hospitals, the clinics, the doctors and n...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Publication date: Available online 15 December 2018Source: Life SciencesAuthor(s): Zhao Ma, Xuebin Bao, Junbao GuAbstractAimFurowanin A (Fur A) is a flavonoid isolated from Millettia pachycarpa Benth. Studies show its potent anti-neoplastic effects against leukemia cells. The aim of the present study was to determine the potential therapeutic effect of Fur A against colorectal cancer (CRC), and elucidate the underlying mechanism.Material and methodsCell Counting Kit-8 (CCK-8) assay was used to determine cell, and TUNEL and Annexin-V/PI staining was used to detect apoptosis and the cell cycle distribution. The expression le...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 15 December 2018Source: Life SciencesAuthor(s): Julia Modesto Vicente, Caio Jordão Teixeira, Junia Carolina Santos-Silva, Dailson Nogueira de Souza, Natália Tobar, Fabiola Sales Furtuoso, Isabel Gouveia Adabo, Frhancielly Shirley Sodré, Gilson Murata, Silvana Bordin, Gabriel Forato AnhêAbstractAimsThe present investigation evaluated whether pregnancy followed by lactation exerts long-term impacts on maternal hepatic lipid metabolism.Main methodsFemale mice were subjected to two pregnancies, after which they were either allowed to breastfeed their pups for 21 d...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 16 December 2018Source: MitochondrionAuthor(s): Justice Afrifa, Tie Zhao, Jingcui YuAbstractThe mitochondria are defined by their unique structure and cellular functions which includes energy production, metabolic regulation, apoptosis, calcium homeostasis, cell proliferation, cell motility and transport as well as free radical generation. Recent advances geared towards enhancing the diagnostic and prognostic value of cancer patients have targeted the circulating mitochondria genome due to its specific and unique characteristics. Circulating mitochondria DNA is known to possess short leng...
Source: Mitochondrion - Category: Biochemistry Source Type: research
Publication date: Available online 16 December 2018Source: The American Journal of SurgeryAuthor(s): Marc Carrier, Alon D. Altman, Normand Blais, Artemis Diamantouros, Deanna McLeod, Uthaman Moodley, Christine Nguyen, Stephanie Young, Frank SchwenterAbstractBackgroundVenous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE). Certain abdominopelvic cancer surgeries are associated with a six to 14-fold increased risk of DVT versus surgeries for benign disease, and extended thromboprophylaxis using perioperative LMWHs may further reduce VTE rates over standard duration administration. This r...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 15 December 2018Source: Respiratory Medicine Case ReportsAuthor(s): Keigo Okamoto, Jun HanaokaAbstractCombined subsegmentectomy (CSS) is procedure as diagnostic purpose adding sufficient surgical margin. Compared to other procedure, CSS is not common, with the surgical results also being controversial. We analyzed the patients who had undergoing CSS in the right upper lobe for ground glass opacity (GGO) -dominant nodules. Between April 2011 and March 2017, we experienced 7 cases underwent CSS. In all cases, three subsegments resection and lymph node dissection using Video-Assisted Thoraci...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Authors: Abstract PMID: 30547738 [PubMed - in process]
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Tags: Curr Cancer Drug Targets Source Type: research
Authors: Sharif K, Coplan L, Lichtbroun B, Amital H Abstract PMID: 30550010 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
CONCLUSIONS: These observations suggest that BDNF Val66met-SNP has no detectable effect on the peripheral neuropathy that is induced by paclitaxel. The significance of BDNF Val66Met-SNP in pre-existing peripheral neuropathy-related conditions, such as diabetes, should be further investigated. PMID: 30550003 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
In this study, we found that TNF-α resulted in an impairment of autophagic flux in microglia. Concomitantly, an increase of M1 marker expression and reduction of M2 marker expression were observed in TNF-α challenged microglia. Upregulation of autophagy via serum deprivation or pharmacologic activators (rapamycin and resveratrol) promoted microglia polarization toward M2 phenotype, as evidenced by suppressed M1 and elevated M2 gene expression, while inhibition of autophagy with 3-MA or Atg5 siRNA consistently aggravated the M1 polarization induced by TNF-α. Moreover, Atg5 knockdown alone was suffic...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: similar clinical results and quality of life were achieved after treating elderly patients with colon cancer with a multidisciplinary management approach. PMID: 30545228 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
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