White Matter Damage in Brain May Help Spot Early Alzheimer's

Title: White Matter Damage in Brain May Help Spot Early Alzheimer'sCategory: Health NewsCreated: 5/27/2015 12:00:00 AMLast Editorial Review: 5/27/2015 12:00:00 AM
Source: MedicineNet Alzheimer - Category: Geriatrics Source Type: news

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Traumatic brain injury (TBI) and Alzheimer's disease (AD) bear a complex relationship, potentially increasing risk of one another reciprocally. However, recent evidence suggests post-TBI dementia exists as a distinct neurodegenerative syndrome, confounding...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
ConclusionsSimilar to AD, the interpretation of [18F]THK5351 uptake in PSP is likely confounded by off-target binding to MAO-B binding sites. [18F]THK5351 is not sufficient in quantifying tau aggregates in PSP using the proposed rasagiline dosing regimen.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Matthew O'Conner presented at Undoing Aging earlier this year on the startup biotech company Underdog Pharmaceuticals. The company is spinning out of the SENS Research Foundation (SRF), based on research conducted by the scientific team there in recent years. The company is focused on a class of molecule known cyclodextrins, and have candidates capable of efficiently binding and sequestering 7-ketocholesterol. This form of oxidized cholesterol is of great importance to the progression of atherosclerosis, and possibly other age-related conditions as well. In the case of atherosclerosis, the presence of oxidized cholesterols...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
Abstract Sigma 1 receptor (σ1), a small transmembrane protein expressed in most human cells participates in modulating the function of other membrane proteins such as G protein coupled receptors and ion channels. Several ligands targeting this receptor are currently in clinical trials for the treatment of Alzheimer's disease, ischemic stroke and neuro-pathic pain. Hence, this receptor has emerged as an attractive target for the treatment of neuro-pathological diseases with unmet medical needs. It is of interest to identify and characterise novelσ1 receptor ligands with different chemical scaffolds usin...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
US experts are curious and skeptical about a new Alzheimer's drug derived from marine algae that was conditionally approved earlier this month by Chinese regulatory authorities for mild-to-moderate AD.Medscape Medical News
Source: Medscape Pharmacist Headlines - Category: Drugs & Pharmacology Tags: Psychiatry News Source Type: news
The microbial populations of the gut influence and are influenced by the state of the immune system. They also have effects on tissue function throughout the body via secreted compounds such as butyrate, mediating some of the effects of diet on long-term health. These microbes change with age, losing beneficial populations and gaining harmful populations that contribute to chronic inflammation. These changes are far from fully explored at the present time, but may have effects on health that rival those resulting from regular exercise. In this open access review, researchers discuss the influence of gut microbes on chronic...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
The mTOR inhibitor rapamycin is well known to slow aging in animal models. As for most of the methods shown to achieve this goal in short-lived species, upregulation of cellular maintenance processes such as autophagy features prominently in the changes produced by the drug. Every one of these approaches that produce sweeping changes in cellular metabolism and a general slowing of age-related decline provides the research community with an essentially unlimited range of projects to undertake when it comes to assessing specific metrics of aging and how they are affected. Here, researchers look at how rapamycin affect...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
(University of California - San Diego) Researchers identified non-coding regions of the human genome that control the development and function of four brain cell types and mapped genetic risk variants for psychiatric diseases. They found that risk variants for Alzheimer's disease were enriched in microglia-specific regulatory elements.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Alzheimer's Association) The Alzheimer's Association and University College London (UCL) are partnering to study brain aging and dementia in 500 individuals whose health and health-related behaviors have been documented since birth. A $7 million grant from the Alzheimer's Association will allow researchers to more accurately detect the influence of both genetics and behaviors on dementia risk across the life course in this unique population.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 13 November 2019Source: Neurología (English Edition)Author(s): F.J. Ros Forteza
Source: Neurologia - Category: Neurology Source Type: research
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