Role of hypofractionated radiotherapy in breast locoregional radiation.

Role of hypofractionated radiotherapy in breast locoregional radiation.
Cancer Radiother. 2015 May 21;
Authors: Caudrelier JM, Truong PT
Abstract
Long-term results of randomised trials have confirmed the safety and efficacy of hypofractionated radiotherapy using approximately 2.6Gy per fraction to lower total doses of 40-42.6Gy delivered over 3weeks, for postoperative treatment of early breast cancer. In these trials, hypofractionated radiotherapy was predominantly used for breast only treatment, while there are fewer trials that specifically examined hypofractionated radiotherapy to the breast plus regional nodes. Hypofractionated locoregional radiation is considered a standard of care in the United Kingdom and in some parts of Canada. We aim to review the radiobiology and normal tissue effects of hypofractionated locoregional radiation and to summarize available published clinical experiences using this treatment strategy as adjuvant therapy after breast conserving surgery or mastectomy for women with early breast cancer.
PMID: 26004842 [PubMed - as supplied by publisher]

Source: Cancer Radiotherapie - May 21, 2015 Category: Cancer & Oncology Authors: Caudrelier JM, Truong PT Tags: Cancer Radiother Source Type: research