Full UPF3B function is critical for neuronal differentiation of neural stem cells

Conclusions:
Together our findings indicate that, despite the down-regulation of NMD factors, functional NMD is critical for neuronal differentiation. We propose that the neurodevelopmental phenotype of UPF3B missense mutation is caused by impairment of NMD function altering neuronal differentiation.

Source: Molecular Brain - May 27, 2015 Category: Neuroscience Authors: Tahani AlrahbeniFrancesca SartorJihan AndersonZosia MiedzybrodzkaColin McCaigBerndt Müller Source Type: research