Enzymatic activity of 38 CYP2C9 genotypes on ibuprofen

CONCLUSION: This is the first systematic evaluation of the catalytic characteristics of 38 CYP2C9 genotypes involved ibuprofen metabolism. Our results provide a corresponding supplement to studies on CYP2C9 gene polymorphisms and kinetic characteristics of different variants. We need to focus on poor metabolizers (PMs) with severely abnormal metabolic functions, because they are more susceptible to drug exposure.PMID:37406757 | DOI:10.1016/j.fct.2023.113926

Source: Food and Chemical Toxicology - July 5, 2023 Category: Food Science Authors: Ling-Jing Yuan Xiang-Yu Li Feng Ye Xin-Yue Li Qing-Qing Li Yun-Shan Zhong Shi-Yu Wang Ya-Hui Wang Guo-Xin Hu Jian-Ping Cai Jun-Wei Li Source Type: research