Leydig cell development in pubertal male rats is blocked by perfluorotetradecanoic acid through decreasing AMPK-mTOR-autophagy pathway

In conclusion, the inhibitory effects of PFTeDA on pubertal rat Leydig cell development are possibly regulated by inducing ferroptosis thereby downregulating SIRT1/AMPKA/ autophagy pathways, eventually resulting in reduced steroidogenesis.PMID:37269911 | DOI:10.1016/j.toxlet.2023.05.012

Source: Toxicology Letters - June 3, 2023 Category: Toxicology Authors: Yunbing Tang Shi Lei Shaowei Wang Han Lu Huitao Li Jieqiang Lv Ren-Shan Ge Yingfen Ying Source Type: research