Drimane-type sesquiterpenoids and their anti-inflammatory evaluation from < em > Pyrrhoderma noxium < /em > HNNU0524

Nat Prod Res. 2023 Jun 1:1-8. doi: 10.1080/14786419.2023.2218008. Online ahead of print.ABSTRACTChemical investigation of a culture broth from the marine-derived fungus Pyrrhoderma noxium HNNU0524 yielded two new compounds including a drimane-type sesquiterpenoid named pyrrnoxin A (1) and a benzoic acid derivative, pyrrnoxin B (5), together with three related known analogues (2-4). The chemical structures of 1 and 5 were determined by detailed analysis of spectroscopic data, single-crystal X-ray crystallography, quantum mechanics-based DP4+ and ECD calculations. Compounds 2 and 3 moderately inhibited NO production of lipopolysaccharide-induced microglia cells BV2 with IC50 values of 26.6 and 60.5 µM, respectively.PMID:37259794 | DOI:10.1080/14786419.2023.2218008

Source: Natural Product Research - June 1, 2023 Category: Biochemistry Authors: Jing-Wen Wang Dong-Yun Liu Hou-Ze Zhang Zhen Tan Cai-Juan Zheng Guang-Ying Chen Xu-Hua Nong Source Type: research