Hope for People with IBD and Those at Risk

Marla Dubinsky, MD Chief, Pediatric Gastroenterology and Hepatology, and Co-Director of the Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center Icahn School of Medicine at Mount Sinai Hope for People with IBD and Those at Risk Up to 1.3 million Americans have inflammatory bowel disease (IBD), a complex disorder of the immune system that results in uncontrolled inflammation of the gastrointestinal (GI) tract. Crohn's disease and ulcerative colitis are the two most common forms of IBD, causing severe GI symptoms, such as diarrhea, abdominal pain, and rectal bleeding, that can wreak havoc with everyday life. These symptoms can often be controlled with medication, but many people still cycle through periods of remission and flare-ups. Deep, long-term remission is possible with certain biologic therapies, but since IBD is a chronic condition with no cure, therapy is life-long. A cure remains elusive because we don't know what causes IBD. However, the recent mapping of the human genome (the complete set of a person's genetic information) has strengthened our grasp of how genes relate to complex immune diseases like IBD. In addition, new knowledge of our digestive system's microbiome (the bacteria and other microscopic organisms living in our gut) has initiated promising research into the role of microbes in IBD. These immense advances have helped us better understand the disease's components, and set the stage for exciting new research that may lead to impr...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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AbstractStrongyloides stercoralis (S. stercoralis), a human intestinal nematode, can lead to hyper/disseminated (HD) infection in patients treated with corticosteroids. Here, we report a case of strongyloidiasis in a 58-year-old female with a history of rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). The patient presented with abdominal pain and gastrointestinal (GI) bleeding. Stool was negative for parasitic agents in the first direct smear examination, and the patient with the probable diagnosis ofHelicobacter pylori (H. pylori) infection or Crohn ’s disease received antibiotics and corticosteroids. ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Conclusion :HL can emerge in IBD patients on immunosuppressive therapy and physicians must be aware of this possibility. EBV infection might have an intermediate role between immunosuppressive treatment and lymphoma. Those data should alert clinicians that, not only thiopurine use but also the disease itself could contribute to a higher occurrence of lymphoproliferative disorders.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 624. Hodgkin Lymphoma and T/NK Cell Lymphoma-Clinical Studies Source Type: research
Authors: Skok P, Kristijan S Abstract Crohn's disease is a chronic inflammatory bowel disease. The disease is characterized by acute exacerbations with diarrhea, abdominal pain, fever, anorexia, intestinal bleeding, and weight loss. Immune-mediated diseases that are frequently associated with Crohn's disease include arthritis, ankylosing spondylitis, sacroiliitis, episcleritis, uveitis, and skin lesions, such as erythema nodosum and pyoderma gangrenosum. The authors present the case of a 22-year-old female patient that was admitted to their hospital due to diarrhea, fever, arthralgias, and diffuse erythematous papu...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - Category: Dermatology Tags: Acta Dermatovenerol Alp Pannonica Adriat Source Type: research
Conclusion Crohn’s disease is a serious disease of the gastrointestinal tract involving inflammation. There is currently no known cause or cure from a conventional medicine perspective, although treatments aim to reduce inflammation and can bring the disease into remission. Holistic approaches address gut dysbiosis, candida and parasites using nutritional supplements, medications and dietary changes. A new vaccine is being developed in England to treat Crohn’s disease by targeting the bacterium MAP found in most Crohn’s patients. The problem with this idea is that MAP has not been shown conclusively to be...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Michelle Goldstein Physical Top Stories Crohn’s disease John Hermon-Taylor MAP (Mycobaterium avium patratuberculosis) St. George’s Hospital Source Type: blogs
Conclusions CD is the most prevalent form of IBD in Saudi children. Male predominance and a high rate of growth failure were documented in children with CD. Clinical presentation, family history and disease localization are comparable to international data.
Source: International Journal of Pediatrics and Adolescent Medicine - Category: Pediatrics Source Type: research
Who said the pharmaceutical industry isn ’t innovative when it comes to communicating with patients? A new graphic novel and superhero devised as part of a first of its kind collaboration looks set to blast that perception out of the water.Japanese behemothTakeda andMarvel Custom Solutions, the content marketing agency offshoot of the comic book publisher, have teamed up as part of a new drive to raise awareness of inflammatory bowel disease (IBD).Called Samarium, the IBD superhero is inspired by the experiences of the IBD patient community, and aims to celebrate the superhero-like qualities of those who live with th...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
Inflammatory bowel diseases, such as Crohn ’s disease (CD) and ulcerative colitis, lead to severe complaints including diarrhea, rectal bleeding, abdominal pain, fatigue, or weight loss in affected patients. These symptoms are caused by a chronic relapsing inflammatory process within the intestinal wall. Acute aggravations of Inflammatory bowel disease need frequent adjustments or changes in therapy to reduce symptoms and prevent severe complications. To enable a quick and appropriate change of therapy, reliable and accurate methods are required to provide an objective assessment of disease activity.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Gastroenterology in Motion Source Type: research
Abstract: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract and includes both Crohn's disease and ulcerative colitis. Patients with IBD often present with abdominal pain, diarrhea, and rectal bleeding but may also have a wide variety of other symptoms such as weight loss, fever, nausea, vomiting, and possibly obstruction. Given that the presentation of IBD is not specific, the differential diagnosis is broad and encompasses a wide spectrum of diseases, many of which can mimic and/or even coexist with IBD. It is important for physicians to differentiate symptoms due to refracto...
Source: Inflammatory Bowel Diseases - Category: Gastroenterology Tags: Clinical Review Article Source Type: research
March is Colon Cancer Awareness Month, today’s TBT post provides some helpful information on colorectal cancer. Michelle was a healthy, active 47 year old. She tried to eat right and she exercised. It looked like the hard work was paying off: no health issues and lots of energy. Her work in the healthcare field motivated her to see her doctors regularly for checkups, to get mammograms and to have her blood work done annually. She knew she was getting close to the magical age of 50 and that soon she would need to get a colonoscopy to screen for colorectal cancer.  Since she had no family history of the disease sh...
Source: Disruptive Women in Health Care - Category: Consumer Health News Authors: Tags: Cancer TBT Source Type: blogs
CONCLUSION: The treatment of chronic inflammatory bowel diseases requires individually designed therapeutic strategies and the close interdisciplinary collaboration of internists and surgeons. PMID: 26900160 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: Journals (General) Tags: Dtsch Arztebl Int Source Type: research
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