Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys

Author Affiliations open 1Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; 2Quintiles, Cambridge, Massachusetts, USA; 3Departments of Biostatistics and 4Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; 5Pediatric Endocrine Division, Departments of Pediatrics and 6Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA; 7Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; 8National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA; 9Department of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia; 10Chapaevsk Medical Association, Chapaevsk, Samara Region, Russia; 11Institute for Forecasting, Russian Academy of Sciences, Moscow, Russia; 12Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan, School of Public Health, Boston, Massachusetts, USA; 13Environmental Health and Engineering, Inc., Needham, Massachusetts, USA; 14EnviroSolutions Consulting, Inc., Auburn, Georgia, USA; 15Axys Analytical Solutions, Sidney, Briti...
Source: EHP Research - Category: Environmental Health Authors: Tags: Children's Health Source Type: research

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As a pediatrician and a parent, I often think about what I’d do to keep my children safe if we were hit by a storm like Hurricane Dorian, which reduced whole towns in the Bahamas to rubble. Or by a wildfire, like the Camp Fire that burned the town of Paradise, California to the ground. Or how we’d deal with this year’s record-breaking rains that flooded scores of towns throughout the Mississippi River Basin. Disasters like these — which may be getting more dangerous with climate change — can directly harm a child’s body. But what’s less well appreciated is how they can harm our chi...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Anxiety and Depression Children's Health Environmental health Source Type: blogs
You're reading 8 Nootropics to Stimulate Your Brain This Fall, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Nootropics is a term coined by Dr. Corneliu E. Giurgea to describe a class of drugs, supplements, and other synthetic and naturally occurring compounds that improve cognitive function in our brains. They’re often called “smart drugs,” as they can help us think faster and more efficiently. Although used by pretty much everyone, these nootropic supplements are especially popular among youn...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness self improvement nootropics pickthebrain Source Type: blogs
 Since time was invented, people have fallen into three main categories: Chronically early, on-time, or late. You don’t need mental illness to put things off until the last minute and it doesn’t take anxiety to get things done well ahead of schedule. But, there’s also no denying that living with mental illness can – and does – impact our ability to be punctual and to accomplish goals. In this episode, Gabe and Michelle discuss the difference between putting things off because we are making bad choices and putting things off because of mental health issues. Listen now! SUBSCRIBE &REVI...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Personal Schizophrenia Self-Help Source Type: blogs
From leisure activities to politics to relationships, people tend to be influenced by their religious beliefs. In this episode, Gabe and Michelle discuss the pros and cons of religious influence when it comes to treating mental illness and explore whether it is helpful when trying to reach recovery. SUBSCRIBE &REVIEW “They are dead (by suicide) and we are still stigmatizing their behavior.” – Gabe Highlights from ‘Religion and Mental Illness’ Episode [2:00] The intersection of religion and mental illness. [4:30] How the Jewish faith views mental illness. [10:00] How Christianity view...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Depression Ethics & Morality Schizophrenia Spirituality & Health Source Type: blogs
In this study, we reviewed major human studies on the health risks of radiation exposure and showed that sex-related factors may potentially influence the long-term response to radiation exposure. Available data suggest that long-term radiosensitivity in women is higher than that in men who receive a comparable dose of radiation. The report on the biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences, United States emphasized that women may be at significantly greater risk of suffering and dying from radiation-induced cancer than men exposed to the same dose of radiation....
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Discussion This case demonstrates successful cure of pre-B-ALL complicating XLA by alloSCT with restoration of B-cell development and functional antibody response. We are aware of only one previous case of pre-B-ALL in an XLA patient (21), which suggests that human BTK deficiency in itself does not predispose to pre-B-ALL. However, there are data to suggest that BTK may act as a tumor suppressor, and BTK deficiency may predispose to tumor development following a “second hit.” Mice with a genetic deficiency in Slp65, a gene encoding an adaptor protein that functions together with BTK, have a block in progenito...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: CAR T cell therapies have demonstrated the clinical benefits of harnessing our body's own defenses to combat tumor cells. Similar research is being conducted on lesser known modifications and gene-modified immune cells, which we highlight in this review. Introduction Chimeric antigen receptors and engineered T cell receptors (based on previously identified high affinity T cell receptors) function by redirecting T cells to a predefined tumor-specific (or tumor-associated) target. Most of these modifications use retroviral or lentiviral vectors to integrate the construct, and most of the receptors ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In conclusion, there are many anti-aging strategies in development, some of which have shown considerable promise for slowing down aging or delaying the onset of age-related diseases. From multiple pre-clinical studies, it appears that upregulation of autophagy through autophagy enhancers, elimination of senescent cells using senolytics, transfusion of plasma from young blood, neurogenesis and BDNF enhancement through specific drugs are promising approaches to sustain normal health during aging and also to postpone age-related diseases. However, these approaches will require critical assessment in clinical trials to determ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 21 December 2018Source: Journal of Cancer PolicyAuthor(s): Tim Eden, Elizabeth Burns, Piera Freccero, Lorna Renner, Vivian Paintsil, Mae Dolendo, Trisha Scanlan, Aye Aye Khaing, Martha Pina, Afiqul Islam, Catherine Chunda-Liyoka, Francine Kouya, Elizabeth MolyneuxAbstractA critical challenge for reducing the cancer survival disparity between children living in low-middle income countries (LMICs) and those in high income countries (HICs) is the apparent lack of consistent supplies of reliable, good quality, effective and affordable essential medicines for curative, supportive and palliativ...
Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research
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