The Unique Genetic Mutation Characteristics Based on Large Panel Next-Generation Sequencing (NGS) Detection in Multiple Primary Lung Cancers (MPLC) Patients

CONCLUSIONS: MPLC has a unique genetic mutation characteristic that differs from advanced patients and usually presents with low TMB. Comprehensive NGS helps to diagnose MPLC and guides the MPLC clinical treatment. ARID1A is significantly enriched in IA nodules containing micro-papillary/solid components, suggesting that these MPLC patients may have a poor prognosis.PMID:37188510 | DOI:10.24976/Discov.Med.202335175.14

Source: Discovery Medicine - May 15, 2023 Category: Research Authors: Zhu Liang Guoxiong Zeng Wang Wan Biao Deng Chunyuan Chen Fasheng Li Guanzhou Lin Yuying Lin Haitao Lin Guixi Mo Huilai Miao Source Type: research