Febuxostat improves endothelial function in hemodialysis patients with hyperuricemia: A randomized controlled study

This study is performed to assess the effect of febuxostat on endothelial dysfunction in hemodialysis patients with hyperuricemia. We randomly assigned 53 hemodialysis patients with hyperuricemia to a febuxostat (10 mg daily) group and a control group and measured flow‐mediated dilation, serum uric acid (UA) levels, systolic and diastolic blood pressure, malondialdehyde‐modified low‐density lipoprotein (MDA‐LDL), and highly sensitive C‐reactive protein (hsCRP) at baseline and at the end of a 4‐week study period. Flow‐mediated dilation increased from 5.3% ± 2.4% to 8.9% ± 3.6% in the febuxostat group but did not change significantly in the control group. Treatment with febuxostat resulted in a significant decrease in serum UA level and a significant decrease in MDA‐LDL compared with baseline, but no significant difference was observed in hsCRP level or blood pressure. No significant differences were observed in the control group. Febuxostat improved endothelial dysfunction and reduced serum UA levels and oxidative stress in hemodialysis patients with hyperuricemia.
Source: Hemodialysis International - Category: Hematology Authors: Tags: Original Article Source Type: research

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Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
AbstractA 53-year-old man on hemodialysis suffered from short bowel syndrome after subtotal colectomy and partial resection of the small intestine. Laboratory tests showed multiple electrolyte disorders and enlarged sodium and chloride ion (Cl−) gaps despite treatment with large volume of sodium chloride replacement via central venous infusion. Blood gas analysis showed slightly high bicarbonate ion levels and metabolic alkalosis was suspected, which is uncommon in end stage kidney disease. The measurement of electrolytes in feces from ileostomy showed relatively high Cl− excretion. The loss of Cl− to fec...
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
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Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
Source: Clinical Epidemiology - Category: Epidemiology Tags: Clinical Epidemiology Source Type: research
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Source: The International Journal of Artificial Organs - Category: Transplant Surgery Authors: Tags: Int J Artif Organs Source Type: research
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Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
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Source: Brazilian Journal of Chemical Engineering - Category: Chemistry Source Type: research
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