Managing Antiseizure Medications in Pregnancy: Is Earlier and More Frequent Monitoring Better?

This study demonstrates that frequency and timing of ASM level monitoring may not affect overall seizure outcomes during pregnancy in those on lamotrigine or levetiracetam. Furthermore, one can consider preemptive dose adjustments or a laboratory-based/clinical-based approach in managing lamotrigine as both seem safe and feasible. However, in those with drug-resistant epilepsy before pregnancy, earlier and closer monitoring is warranted given the risk of seizures early during pregnancy. Larger prospective studies are needed to confirm these results.

Source: Neurology Clinical Practice - May 22, 2023 Category: Neurology Authors: Freund, B., Chen, B., Kaplan, P. W., Johnson, E. L. Tags: Gender, All Epilepsy/Seizures, Antiepileptic drugs, Generalized seizures, Partial seizures Research Article Source Type: research