Molecules, Vol. 28, Pages 4215: Thiocarbonyl Derivatives of Natural Chlorins: Synthesis Using Lawesson & rsquo;s Reagent and a Study of Their Properties

Molecules, Vol. 28, Pages 4215: Thiocarbonyl Derivatives of Natural Chlorins: Synthesis Using Lawesson’s Reagent and a Study of Their Properties Molecules doi: 10.3390/molecules28104215 Authors: Viktor Pogorilyy Petr Ostroverkhov Valeria Efimova Ekaterina Plotnikova Olga Bezborodova Ekaterina Diachkova Yuriy Vasil’ev Andrei Pankratov Mikhail Grin The development of sulfur-containing pharmaceutical compounds is important in the advancement of medicinal chemistry. Photosensitizers (PS) that acquire new properties upon incorporation of sulfur-containing groups or individual sulfur atoms into their structure are not neglected, either. In this work, a synthesis of sulfur-containing derivatives of natural chlorophyll a using Lawesson’s reagent was optimized. Thiocarbonyl chlorins were shown to have a significant bathochromic shift in the absorption and fluorescence bands. The feasibility of functionalizing the thiocarbonyl group at the macrocycle periphery by formation of a Pt(II) metal complex in the chemotherapeutic agent cisplatin was shown. The chemical stability of the resulting conjugate in aqueous solution was studied, and it was found to possess a high cytotoxic activity against sarcoma S37 tumor cells that results from the combined photodynamic and chemotherapeutic effect on these cells.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research