New chemical technology boosts potency of targeted cancer therapy

A new chemical technology uses cancer cells' own protein-degrading machinery to destroy, rather than merely inhibit, cancer proteins. Researchers developed the strategy as a way to develop inhibitors of "undruggable" proteins and overcome drug resistance, a common shortcoming of targeted therapies. Resistance arises when tumors that originally responded to a particular therapy manage to circumvent the drug's effects and resume their growth.
Source: ScienceDaily Headlines - Category: Science Source Type: news

Related Links:

Publication date: 1 February 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 174Author(s): Pradip Das, Miriam Colombo, Davide ProsperiAbstractRecently, magnetic fluid hyperthermia using biocompatible magnetic nanoparticles as heat mediators for cancer therapy has been extensively investigated due to its high efficiency and limited side effects. However, the development of more efficient heat nanomediators that exhibit very high specific absorption rate (SAR) value is essential for clinical application to overcome the several restrictions previously encountered due to the large quantity of nanomaterial required f...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Researchers from The University of Texas MD Anderson Cancer Center found that the nauseating procedure resolved severe colitis in two patients who developed the disease following cancer therapy.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusion: Propolis extracts may be important economically, allowing a relatively inexpensive cancer treatment associated to lower concentrations of drugs. In this review, the activity and mechanisms of action of propolis and CAPE on breast cancer cells are discussed.
Source: Current Pharmacogenomics and Personalized Medicine - Category: Genetics & Stem Cells Source Type: research
Conclusion: The ethanol ADH acetaldehyde system offers a simple, safe, non-toxic approach to cancer therapy prodrug toxin technology. It may also offer a safe and non-toxic system to control the number and action of T cells used in adoptive immunotherapy.
Source: Current Pharmacogenomics and Personalized Medicine - Category: Genetics & Stem Cells Source Type: research
Conclusion: A reliable, safe, effective and collective platform can be established through further scientific and technical approaches in the clinic.
Source: Current Pharmacogenomics and Personalized Medicine - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Dan Liu, Xiaoxi Li, Xintian Chen, Yu Sun, Anqun Tang, Zhongwei Li, Junnian Zheng, Ming ShiAbstractThe treatment of cancer has made great progress. However, drug resistance remains problematic. Multiple physiologic processes of tumor development can be dominated by central and sympathetic nervous systems. The interactions between the nervous system, immune system, and tumor occur consistently and dynamically. Recent evidence suggests that nerves and neural signals are intimately involved in the develop...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research
Publication date: Available online 7 November 2018Source: Materials Science and Engineering: CAuthor(s): María J. Limeres, Marcela A. Moretton, Ezequiel Bernabeu, Diego A. Chiappetta, María L. CuestasAbstractNanotechnology has recently emerged as a promising tool in biomedicine research. An important branch of nanotechnology is drug delivery and drug targeting using a wide range of biomaterials with promising potential applications in cancer research. The aim of this review is to provide an overview of the evolution of nanotechnology in cancer therapy, exemplified by a myriad of applications in drug delivery,...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this study, we report a smart and green strategy to synthesize copper sulfide nanoparticles (CuS-NPs) for clinically translatable cancer treatment. For the first time, the preparation of CuS-NPs was developed by taking advantage of the copper-amine complex as the copper source and sodium sulfide as the sulfide source, in which the quaternized chitosan (QCS) was used as a biotemplate and stabilizing agent. The obtained QCS/CuS-NPs composites (CuS@QCS-NPs) were spherical and stable with an average diameter of 5.6 nm, and showed strong NIR absorbance for photothermal conversion. Moreover, in vitro and in vivo cancer ther...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Follicular activation with granulosa conditioned medium. AbstractFertility preservation of prepubertal girls subjected to invasive cancer therapy necessitates defining protocols for activation of isolated primordial follicles. Granulosa (GCs) and cumulus cells (CCs) play pivotal role in oocyte development. Although GCs and CCs share some similarities, they differ in growth factors production. The current study was conducted to evaluate the effects of GCs, CCs and their conditioned media on mice primordial follicles activation. One ‐day‐old mice ovaries were subjected to 6‐day culture with base medium (BM), GC conditi...
Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
This study will contribute to explaning the origin of lung cancer stem cells and to elucidate the role of cell fusion in cancer metastasis.
Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
More News: Cancer | Cancer & Oncology | Cancer Therapy | Chemistry | Science