Access, Excess, And Medical Transformation: Delivering Durable Health Care In Rural Nepal
Conclusion: On Impact And Scale We believe that Durable Healthcare can transform the health care industry away from the dominant fee-for-service paradigm and towards a model that incentivizes patient safety, patient-centeredness, and evidence-based medicine. Only then we will have a competitive marketplace of private sector providers who leverage public funds for the broader public good.
CONCLUSIONS: Despite modern advances in screening, management, and interventional measures for CVD, rising trends in CVD risk factors across all sex and race/ethnic groups call for attention by preventive cardiologists. PMID: 32483642 [PubMed - in process]
The coronavirus disease 2019 (COVID-19), seems to have a cardiovascular tropism characterized by high incidence of myocardial infarction especially for patients with severe infections recovered in intensive care units. In their letter, the Authors state that oxidative stress could play a pivotal role to determine cardiovascular complications in COVID-19. We agree about this issue. In particular, NADPH oxidase-2 (NOX-2), that it is considered one of the most important sources of superoxide anion in human , plays a role in systemic inflammation and pathogenesis of several RNA virus as the influenza virus .
In a recent  retrospective analysis in 325 non-valvular atrial fibrillation (NVAF) patients treated with novel oral anticoagulants (NOAC), authors suggested a higher risk of thrombosis in obese/overweight vs. other patients, particularly those treated with dabigatran; and a higher risk of bleeding, particularly related to factor Xa inhibitors (rivaroxaban, apixaban). They proposed that obesity moderated the NOAC effects, differently for different NOACs. However a) the study did not test for moderation [(warfarin vs.
We have read an experimental study entitled “miR-135b protects cardiomyocytes from infarction through restraining the NLRP3/caspase-1/IL-1β pathway” written by Li and his colleagues . They demonstrated that miR-135b overexpression remarkably restored impaired cardiac function caused by myocardial infarction(MI)via restraining pyroptos is pathway.
Recently, we have read with great interest Dr. Zhao and colleagues' article entitled “Circulating Serpina3 levels predict the major adverse cardiac events in patients with myocardial infarction”  that published in International Journal of Cardiology. In this article, they draw a conclusion that the concentrations of serpina3 prospectively predict the development of major adve rse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI).
Conclusions. LDL-C is the lipid fraction strongest associated with younger age of presentation of first MI. These results support the importance of controlling and treating LDL-C in prevention of premature MI. PMID: 32483990 [PubMed - as supplied by publisher]
Objectives: A previous pilot study demonstrated that various fixed-dose combinations (FDCs) of ibuprofen (IBU) and acetaminophen (APAP) provided analgesic efficacy comparable to a higher dose of IBU, with the same safety profile. These studies further evaluated the chosen FDC IBU/APAP 250/500 mg formulation. Materials and Methods: Two phase 3 dental pain studies enrolled healthy young patients with ≥moderate pain after ≥3 third molar extractions who received single-dose FDC IBU/APAP 250/500 mg, IBU 250 mg, APAP 650 mg, or placebo evaluated over 12 hours (study 1) or multiple-dose FDC ...
Discussion: Recovery is a multidimensional and complex construct. In addition to pain intensity and disability, measurement and conceptualization of recovery should focus on emotional well-being, self-perception, and the cultural values and beliefs of the individual. A positive therapeutic relationship, with attention to psychological and social influences, appears to be important in facilitating recovery and well-being.
This study aimed to develop a method that objectively measures the clinical benefits of ketamine infusions to treat complex regional pain syndrome (CRPS), thus making it possible, for the first time, to determine the optimal dosing of ketamine and duration of treatment to treat CRPS. Materials and Methods: All patients were diagnosed with hyperalgesia associated with CRPS. Patients underwent an outpatient, 4-day, escalating dose ketamine infusion. Hyperalgesia was measured using pain thresholds. Clinical outcome was determined without knowledge of the patient’s pain thresholds throughout treatment. Results: We ...
Discussion: The current study confirmed that individuals preparing a movement attended more toward somatosensory stimuli at the lower back when anticipating back pain during the movement, as measured by the N96 SEP. However, no differences were found between participants with chronic low back pain or recurrent low back pain, or the pain-free controls.
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