Cytotoxicity sesquiterpenoids from the leaves of < em > Datura stramonium < /em > L

Nat Prod Res. 2023 May 17:1-8. doi: 10.1080/14786419.2023.2214292. Online ahead of print.ABSTRACTFour new sesquiterpenoids, dstramonins A-D (1-4), and one new natural product (5), together with three known compounds (6-8), were isolated from the leaves of Datura stramonium L. The structures of new compounds were elucidated by extensive spectroscopic analysis and comparison with the literature. The cytotoxicity of isolates against LN229 cells was assessed and compounds 2-4, and 7 displayed cytotoxic activity with IC50 values ranging from 8.03 to 13.83 μM.PMID:37198914 | DOI:10.1080/14786419.2023.2214292

Source: Natural Product Research - May 18, 2023 Category: Biochemistry Authors: Juan Pan Yan Liu Ao-Fei Wang Jia-Tong Wu Rui Yang Wei Guan Adnan Mohammed Algradi Hai-Xue Kuang Bing-You Yang Source Type: research