Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function are major determinants of endotoxin-induced insulin resistance

Conclusion:
Nitric oxide excess and LPS impairs glycemic control by diminishing MGU. LPS impairs MGU by both the direct effect of inflammation on the myocyte, as well as by the indirect NO-driven cardiovascular dysfunction.

Source: Cardiovascular Diabetology - May 20, 2015 Category: Cardiology Authors: Lawrence HouseRobert MorrisTammy BarnesLouise LantierTravis CyphertOwen McGuinnessYolanda Otero Source Type: research