Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET

CONCLUSION: The FLUKA MC based tool was able to optimize proton treatment plans taking the tumor pO2 distribution from hypoxia PET images into account. Independent of RBE-model, both elevated LET and physical dose were found in the hypoxic regions, which shows the potential to increase the tumor control compared to a conventional optimization approach.PMID:37161820 | DOI:10.1002/acm2.14014

Source: Cancer Control - May 10, 2023 Category: Cancer & Oncology Authors: Helge Henjum Tordis Johnsen Dahle Andrea Mairani Sara Pilskog Camilla Stokkev åg Camilla Grindeland Boer Kathrine R øe Redalen Heikki Minn Eirik Malinen Kristian Smeland Ytre-Hauge Source Type: research