Crystallization of interleukin-18 for structure-based inhibitor design

In this study, surface-entropy reduction (SER) and rational protein design were employed to facilitate the crystallization of hIL-18. The results provide an excellent platform for structure-based drug design.

Source: Acta Crystallographica Section F - May 20, 2015 Category: Biochemistry Authors: Krumm, B.Meng, X.Xiang, Y.Deng, J. Tags: cytokines interleukin-18 immune defense surface-entropy reduction research communications Source Type: research