ED sedation with droperidol is relatively safe and effective

This study has shown that droperidol is relatively safe and effective for the management of violent and aggressive patients in the ED and that there was no increased risk of QT prolongation and torsades de points according to a large cohort of cases.” The “Editor’s Capsule Summary” that accompanies the article is even more emphatic*: How this is relevant to clinical practice Droperidol is safe even with the high doses used in this study. The authors note that the study does not rule out that droperidol may be associated with rare cases of torsades. But the agitated, delirious ED patient may be a danger to himself, staff, and other patients, and may have underlying serious medical problems that must be addressed emergently. The need to get control of the situation by using chemical restraints is crucial, and certainly trumps what is clearly a very small risk of prolonging the QT interval. *The original post was updated to include the “Editor’s Capsule Summary” conclusion. Related post:   FDA Warnings: Black Box, or Black Hole?  
Source: The Poison Review - Category: Toxicology Authors: Tags: Best of TPR Medical black box warning droperidol FDA food and drug administration QT prolongation torsades de pointes Source Type: news

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BACKGROUND: Poisoned patients are frequently admitted following Emergency Department (ED) presentation, while the necessity of such admissions is hardly investigated. We determined the proportion and characteristics of poisoned patients who were admitted, ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Publication date: September 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 55Author(s): Nasim Zamani, Hossein Hassanian-Moghaddam, Hooman Bahrami-Motlagh, Sara Ahmadi, Scott PhillipsAbstractObjectivesOur study attempts to determine if for patients following ingestion of lead-contaminated opium, radiographs [plain X-ray (KUB)] or unenhanced computed tomography (CT scan) of the abdomen may be predictive of lead poisoning.MethodsOur study is concerned with patients of>21 years with elevated lead concentrations, who had undergone KUB or CT. Patients with other toxicities who had undergone similar imag...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
"One man's food is another man's poison." - Lucretius (99-55 B.C.)
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Authors: Ota T, Nakano Y, Mizuno T, Shiozaki A, Hori Y, Yamanishi K, Hayakawa K, Hayakawa T, Fujimoto T, Nakamoto C, Mejima K, Wada Y, Terasoma F, Ohnishi T Abstract Along with the increase in consumption of raw animal meat, the prevalence of food poisoning is increasing. A 67-year-old Japanese man had eaten raw venison 4 hours prior to the beginning of vomiting. Many white cysts were discovered in the venison, with numerous bradyzoites being detected after the cysts were punctured. The presence of the Sarcocystis spp. 18S rRNA gene was detected by polymerase chain reaction, and Sarcocystis truncata was isolated fr...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: Available online 22 May 2019Source: Journal of Forensic and Legal MedicineAuthor(s): Utsav Parekh, Sanjay GuptaAbstractPoisoning is recognized as a major factor for deaths in majority of low-income and middle- income countries. Although it is considered as a global burden, the nature of poisoning may vary in different areas across the world. The Charutar region in the state of Gujarat in western India has a unique topography and cultivation practises which sets it apart from the rest of the state. Due to the dearth of studies pertaining to the access of the population at this area to different types of po...
Source: Journal of Forensic and Legal Medicine - Category: Forensic Medicine Source Type: research
Publication date: Available online 22 May 2019Source: Journal of Forensic and Legal MedicineAuthor(s): Elena Azzalini, Marzia Bernini, Sara Vezzoli, Anna Antonietti, Andrea Verzeletti
Source: Journal of Forensic and Legal Medicine - Category: Forensic Medicine Source Type: research
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Source: Journal of Forensic and Legal Medicine - Category: Forensic Medicine Source Type: research
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Source: Gut Pathogens - Category: Microbiology Source Type: research
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Source: International Journal of Legal Medicine - Category: Medical Law Source Type: research
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