A case of squamous cell carcinoma of the skin due to the molecularly confirmed Lynch Syndrome

Abstract Patients with Lynch Syndrome are at high risk for developing a variety of cancers including cancers of the colon or rectum, small bowel, stomach, uterus, renal pelvis, ureter, biliary tract, ovaries, brain and pancreas (N Engl J Med 348: 919-32, 2003; Gut 57:1097-101, 2008; NCCN, Inc Guideline. Ft. Washington, PA. Online Version 2.2014). Lack of MLH-1 and MSH-2 expression commonly result from germline mutations in this inherited cancer syndrome. Here, we report the case of a patient with a molecularly confirmed germline mutation in MLH-1 along with a colon cancer showing lack of expression of MLH-1 as well as a squamous cell cancer of the skin from the abdominal wall also demonstrating lack of expression of MLH-1. This case appears to represent the second case report of a squamous cell skin cancer apparently due to the Lynch Syndrome and further supports a proposed relationship between Lynch Syndrome and these tumors.
Source: Hereditary Cancer in Clinical Practice - Category: Cancer & Oncology Source Type: research

Related Links:

Publication date: Available online 3 June 2020Source: Journal of the American College of RadiologyAuthor(s): Ruth C. Carlos, Katy Lowry, Gelareh Sadigh
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
Conclusion. The spontaneous incidence rate of vertebral body infection among OVF patients was 0.7%; however, the occurrence of this complication led to serious events. Clinicians should pay attention to the possibility of bacillemia in elderly or immunocompromised OVF patients. Level of Evidence: 4
Source: Spine - Category: Orthopaedics Tags: CLINICAL CASE SERIES Source Type: research
Conclusion. The proposed nomogram obtained more precision prognostic prediction for patients with initially-diagnosed primary spinal and pelvic tumors. Level of Evidence: 3
Source: Spine - Category: Orthopaedics Tags: HEALTH SERVICES RESEARCH Source Type: research
Study Design.. A meta-analysis. Objective.. The goal of this study was to accurately evaluate the risk ratio (RR) of recurrence in chordoma patients with wide margin after removing the tumors using surgery, compared with inadequate margin (intralesional or marginal). Summary of Background Data.. As a rare malignant bone cancer, the more effective treatment for sacral chordoma is still surgical resection. However, there is no convincing evidence and risk ratio about sacral chordoma patients would be benefit from which kind of surgical margin. Methods.. We searched the PubMed, Cochrane Library, Web of Science, and...
Source: Spine - Category: Orthopaedics Tags: LITERATURE REVIEW Source Type: research
Conclusion. Patients with positive surgical margins benefit from adjuvant RT. Optimal OS is associated with adjuvant RT administered with advanced techniques and cumulative dose more than 65 Gy. Level of Evidence: 4
Source: Spine - Category: Orthopaedics Tags: SURGERY Source Type: research
Authors: Carkic J, Nikolic N, Nisevic J, Lazarevic M, Kuzmanovic-Pficer J, Jelovac D, Milasin J Abstract Oral carcinoma is the sixth most common malignancy worldwide, with survival rates of approximately 50%. The major type of oral cancer, present in 90% of the cases, is oral squamous cell carcinoma (OSCC). The genetic background predisposing an individual to OSCC is complex and largely unknown. Studies have suggested that endothelial nitric oxide synthase (eNOS) gene polymorphisms modulate the cancer risk, prompting us to assess the impact of three functional eNOS gene polymorphisms on OSCC risk. The present study...
Source: Journal of oral science - Category: Dentistry Tags: J Oral Sci Source Type: research
Purpose of review Genome instability has long been implicated as a primary causal factor in cancer and diseases of aging. The genome is constantly under attack from extrinsic and intrinsic damaging agents. Uracil misincorporation in DNA and its repair is an intrinsic factor resulting in genomic instability and DNA mutations. Additionally, the presence of uracil in DNA can modify gene expression by interfering with promoter binding and transcription inhibition or upregulation of apoptotic proteins. In immune cells, uracil in DNA drives beneficial genomic diversity for antigen-driven immunity. This review addresses disease...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - Category: Nutrition Tags: GENES AND CELL METABOLISM: Edited by Anastasia Z. Kalea and Dorothy Klimis-Zacas Source Type: research
Publication date: Available online 5 June 2020Source: Journal of the Formosan Medical AssociationAuthor(s): Po-Ting Lin, Wei Teng, Wen-Juei Jeng, Chun-Yen Lin
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Conclusion: Both ESTD and ESD are safe and effective therapies for early-stage esophageal cancer wider than or equal to one half the esophageal circumference. The dissection speed of ESTD is faster than that of ESD.
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
CONCLUSION: A hybrid robotic transanal minimally invasive surgery approach allows for complete resection of very large polyps, which would otherwise be extremely challenging with standard transanal approaches. See Video at http://links.lww.com/DCR/B231.
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Technical Note Source Type: research
More News: Brain | Brain Cancers | Cancer | Cancer & Oncology | Cancer of the Uterus | Carcinoma | Colon Cancer | Colorectal Cancer | Gastric (Stomach) Cancer | HNPCC | Lynch Syndrome | Neurology | Ovarian Cancer | Ovaries | Pancreas | Pancreatic Cancer | Skin | Skin Cancer | Squamous Cell Carcinoma | Ureter and Renal Pelvis Cancer