Endotoxin-induced skeletal muscle wasting is prevented by angiotensin (1-7) through a p38 MAPK dependent mechanism
Skeletal muscle atrophy induced during sepsis syndrome produced by endotoxin as lipopolisaccharide (LPS), is a pathological condition characterized by the loss of strength and muscle mass, an increase in myosin heavy chain (MHC) degradation, and an increase in the expression of atrogin-1 and MuRF-1, two ubiquitin E3 ligases belonging to ubiquitin-proteasome system. Angiotensin (1-7) [Ang (1-7)], through its Mas receptor, produces beneficial effects in skeletal muscle. We evaluated in vivo the role of Ang (1-7) and Mas receptor on the muscle wasting induced by LPS injection to C57BL/10J mice. Studies in vitro were performed in murine myotubes C2C12 and isolated myofibres from EDL muscle. Additionally was evaluated the participation of p38 MAPK in the Ang (1-7) effect on the LPS-induced muscle atrophy. Our results show that Ang (1-7) prevents the decrease in diameter of myofibres and myotubes, the decrease in muscle strength, the diminution in MHC levels and the induction of atrogin-1 and MuRF-1 expression, all of them induced by LPS. These effects were reversed by using A779, a Mas antagonist. Ang (1-7) exerts these anti-atrophic events at least in part by inhibiting the LPS-dependent activation of p38MAPK both in vitro and in vivo. We demonstrated for the first time that Ang (1-7) counteracts the skeletal muscle atrophy induced by endotoxin through a mechanism dependent on the Mas receptor that involves a decrease in p38 MAPK phosphorylation. Our study indicates that Ang (1-7...
Authors: Stange EF, Schroeder BO Abstract Introduction: Inflammatory bowel diseases (IBD) are on the rise worldwide. This review covers the current concepts of the etiology of Crohn´s disease and ulcerative colitis by focusing on an unbalanced interaction between the intestinal microbiota and the mucosal barrier. Understanding these issues is of paramount importance for the development of targeted therapies aiming at the disease cause. Area covered: Gut microbiota alterations and a dysfunctional intestinal mucosa are associated with IBD. Here we focus on specific defense structures of the mucosal barrier, nam...
ConclusionsOromotor exercises are more effective than incentive spirometry training in improving both pulmonary and oromotor functions in children with Down's syndrome.
Publication date: Available online 11 October 2019Source: Journal of Taibah University Medical SciencesAuthor(s): Beuy Joob, Viroj Wiwanitkit
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Publication date: Available online 11 October 2019Source: The SurgeonAuthor(s): Gregory L. Falk
ConclusionsPatients receiving perioperative gabapentin, acetaminophen, and NSAIDs under an ERAS protocol required significantly fewer narcotics and shorter length of stay. This protocol may merit consideration for use at other centers.
ConclusionsMore than half (51%) of women who underwent genetic counseling and received an uninformative negative genetic test result had a significantly elevated risk for the development of breast cancer. It is, therefore, imperative that women do not conclude that a negative genetic test result represents a lack of risk.
Publication date: Available online 11 October 2019Source: The American Journal of SurgeryAuthor(s): Dhruv J. Patel, Waseem Lutfi, Patrick Sweigert, Emanuel Eguia, Gerard Abood, Lawrence Knab, Paul C. Kuo, Marshall S. BakerAbstractBackgroundPrior studies of adjuvant systemic therapy in pancreatic acinar cell carcinoma have been underpowered.MethodsWe queried the National Cancer Data Base to identify patients presenting with resectable (clinical stage I and II) acinar cell carcinoma between 2004 and 2015. Multivariable Cox Regression was used to evaluate the association between overall survival and systemic therapy.Results29...
ConclusionOur pilot curriculum addresses a gap in resident education about surgical cost. Residents generally regard equipment standardization as either improving or not changing hospital metrics.