Chemical constituents from the heterotrophic marine microalgae < em > Aurantiochytrium < /em > sp. SC145 and their antimicrobial activities

Nat Prod Res. 2023 Apr 22:1-7. doi: 10.1080/14786419.2023.2201882. Online ahead of print.ABSTRACTOne new indol, N-methoxymethyltryptophol (1), one new phenolic, (2 R)-2-(4-hydroxyphenyl)ethyl 2-hydroxy-3-phenylpropanoate (2) and fifteen known compounds (3-17) were isolated from the methanol extract of the fermentation of marine microalgae Aurantiochytrium sp. SC145. Their structures were elucidated by 1D-, 2D-NMR spectroscopic analysis, HR-ESI-MS, quantum chemical calculation methods and by comparing their NMR data with those reported in the literature. All compounds were evaluated for their antimicrobial activities against microorganisms. Compounds 2, 3 and 11 significantly exhibited antimicrobial activities on all tested Gram-(+), Gram-(-) bacteria and the yeast C. albicans with MIC values ranging from 32 to 256 µg/mL.PMID:37086471 | DOI:10.1080/14786419.2023.2201882
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research
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