Chemical constituents from the heterotrophic marine microalgae < em > Aurantiochytrium < /em > sp. SC145 and their antimicrobial activities

Nat Prod Res. 2023 Apr 22:1-7. doi: 10.1080/14786419.2023.2201882. Online ahead of print.ABSTRACTOne new indol, N-methoxymethyltryptophol (1), one new phenolic, (2 R)-2-(4-hydroxyphenyl)ethyl 2-hydroxy-3-phenylpropanoate (2) and fifteen known compounds (3-17) were isolated from the methanol extract of the fermentation of marine microalgae Aurantiochytrium sp. SC145. Their structures were elucidated by 1D-, 2D-NMR spectroscopic analysis, HR-ESI-MS, quantum chemical calculation methods and by comparing their NMR data with those reported in the literature. All compounds were evaluated for their antimicrobial activities against microorganisms. Compounds 2, 3 and 11 significantly exhibited antimicrobial activities on all tested Gram-(+), Gram-(-) bacteria and the yeast C. albicans with MIC values ranging from 32 to 256 µg/mL.PMID:37086471 | DOI:10.1080/14786419.2023.2201882

Source: Natural Product Research - April 22, 2023 Category: Biochemistry Authors: Nguyen Thi Thu Thuy Hoang Thi Minh Hien Nguyen Cam Ha Le Thi Thom Dang Diem Hong Nguyen Van Thinh Nguyen Trong Dan Nguyen Dang Hoi Vu Thi Loan Hoang Duc Quang Dan Thi Thuy Hang Phan Van Kiem Bui Huu Tai Nguyen Thi Minh Hang Nguyen Tien Dat Nguyen Xuan Nhi Source Type: research