Three undescribed coumarins from the roots of < em > Angelica pubescens < /em >

Nat Prod Res. 2023 Apr 12:1-7. doi: 10.1080/14786419.2023.2200185. Online ahead of print.ABSTRACTThree undescribed coumarins, 6-(3-hydroxy-3-methyl-2-oxobutyl)-7-methoxycoumarin (1), (R)-6-(1,3-dihydroxy-3-methyl-2-oxobutyl)-7-methoxycoumarin (2), angelol N (6), together with four known coumarins were isolated from the roots of Angelica pubescens. Their structures were determined by extensive spectroscopic analyses. The absolute configurations of compounds 2 and 6 were assigned via electronic circular dichroism (ECD). Their inhibitory effects on lipopoly-saccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells were evaluated. Compounds 1-4 exhibited moderate inhibitory activities.PMID:37042679 | DOI:10.1080/14786419.2023.2200185

Source: Natural Product Research - April 12, 2023 Category: Biochemistry Authors: Fuyong Ni Xue Xie Xue Huai Xiao Yu Hongda Zhang Ming Li Jianhui Wen Ming Yan Chenfeng Zhang Zhenzhong Wang Wei Xiao Source Type: research