Anti-Lactosylceramide antibody positive combined central peripheral demyelination emerging from long-standing juvenile-onset chronic inflammatory polyradiculoneuropathy; a report of two cases

Anti-Lactosylceramide (LacCer) antibodies are associated with neurological inflammation involving both the peripheral and central nervous system (PNS, CNS respectively), however, the documented number of cases is small. Uncertainty remains whether its positivity can identify a unique clinical entity. Here, we describe two anti-LacCer antibody positive cases, both with long histories (> 30  years) of teenage-diagnosed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). CNS lesions including the medulla oblongata were observed for the first time in adulthood.

Source: Journal of Neuroimmunology - April 10, 2023 Category: Allergy & Immunology Authors: Naoki Takegami, Kaori Sakuishi, Nanaka Yamaguchi-Takegami, Shuhei Egashira, Shogo Komaki, Tatsuro Mutoh, Tatsushi Toda Tags: Short Communication Source Type: research