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Mayo Clinic Study Finds Losing Weight Can Reduce Risk of Death and Ventilator Use in Lung Transplant Patients

ROCHESTER, Minn. — Obesity is a complicating factor for many surgical patients. In a recent study published in the Journal of Heart and Lung Transplantation, Mayo Clinic researchers have shown that losing weight can have a positive impact on outcomes for lung transplant patients. In the manuscript, “Weight loss prior to lung transplantation is associated [...]
Source: Mayo Clinic Rochester News - Category: Hospital Management Source Type: news

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Leptin is secreted by adipocytes, induces satiety via central mechanisms, and stimulates lipolysis and fatty acid utilization. Cardiac cachexia has been associated with worse outcomes in chronic heart failure (HF), and the role of leptin is poorly understood. We hypothesized that patients in chronic HF with low leptin levels would have worse outcomes and that leptin would modify the relationship of body mass index (BMI) with HF progression.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
The obesity paradox in heart failure indicates that overweight and obese patients have better survival compared to those with normal BMI. However, little is known about the impact of BMI in patients supported by CF-LVAD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Body mass index (BMI)
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Device infections still remains a frequent complication after continuous flow left ventricular assist device (CF-LVAD) implantation. Although obesity has been demonstrated to be a significant risk factor for mortality in patients undergoing heart transplantation, there is a paucity of data on the effect of obesity on outcomes in patients undergoing CF-LVAD implantation. The purpose of this study was to analyze the effect of obesity on outcomes after CF-LVAD implantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Donor body-mass index (BMI) has been increasing over time, although donor BMI remains lower on average than heart transplant recipient BMI. There is limited data regarding the use of allograft hearts from donors with obesity. Our purpose was to assess the outcome of performing heart transplantation from donors with BMI> 35 kg/m2.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Bariatric surgery is a well documented surgical procedure for achieving substantial weight loss in morbidly obese patients. However, there is a paucity of data examining its safety and efficacy in patients with continuous flow left ventricular assist devices (CF-LVADs) as a mechanism to achieve adequate weight loss for purposes of being considered for heart transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
High body mass index (BMI) is associated with increased risk of acute cellular rejection (ACR) in renal and cardiac transplant recipients. Despite advances in immunosuppressive therapies, ACR continues to occur in more than a third of recipients in the first year post lung transplant (LTx). Although there is data on the association between primary graft dysfunction and obesity in LTx, the effect of BMI on the incidence of ACR has not been examined.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Conclusions Malnutrition is associated with increased mortality and other unfavorable echocardiographic and clinical outcomes compared with those of NB. The same effect of obesity on survival was not observed. Further studies are needed investigating the long-term impact of abnormal anthropometric measurements on outcomes in pediatric DCM. (Pediatric Cardiomyopathy Registry; NCT00005391) Graphical abstract
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
More News: Cardiology | Eating Disorders & Weight Management | Heart | Heart Transplant | Hospital Management | Lung Transplant | Obesity | Study | Transplant Surgery | Transplants