Phenolics and triterpenoids from stem bark of < em > Calophyllum lanigerum var. austrocoriaceum < /em > (Whitmore) P. F. Stevens and their cytotoxic activities

In this study, four known phenolic constituents and two triterpenoids have been isolated from the stem bark of Calophyllum lanigerum. The compounds were two pyranochromanone acids are known as caloteysmannic acid (1), isocalolongic acid (2), a simple dihydroxyxanthone, namely euxanthone (3), one coumarin named calanone (4), and two common triterpenoids, friedelin (5), and stigmasterol (6). Chromanone acids were reported for the first time in this Calophyllum species. Cytotoxic evaluations were carried out on n-hexane extract (87.14 ± 2.04 µg/mL; 81.46 ± 2.42 µg/mL) followed by the chromanone acids (1 [79.96 ± 2.39 µM; 83.41 ± 3.39 µM] & 2 [57.88 ± 2.34; 53.04 ± 3.18 µM]) against two cancerous cell lines, MDA-MB-231 and MG-63 cell lines, respectively. The results showed that all tested samples exhibited moderate cytotoxicity.PMID:37005001 | DOI:10.1080/14786419.2023.2196075

Source: Natural Product Research - April 2, 2023 Category: Biochemistry Authors: Norisha Mokhtar Thiruventhan Karunakaran Rameshkumar Santhanam Mohamad Hafizi Abu Bakar Vivien Yi Mian Jong Source Type: research