Low-dose Methylphenidate Monotherapy for Features of Attention-Deficit/Hyperactivity Disorder Secondary to Hereditary Cerebellar Ataxia.

Low-dose Methylphenidate Monotherapy for Features of Attention-Deficit/Hyperactivity Disorder Secondary to Hereditary Cerebellar Ataxia. CNS Neurosci Ther. 2015 May 15; Authors: Hu LY, Lin YL, Chang HS, Lu T, Lin WS PMID: 25976218 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Tags: CNS Neurosci Ther Source Type: research

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Conditions:   Behavioral Symptoms;   Behavioral Problem;   Emotional Problem;   Emotional Stress;   ADHD;   Emotional Disorder;   Depression, Anxiety;   Conduct Disorder;   Emotional Trauma Interventions:   Behavioral: WHO School Mental Health Program;   Behavioral: Enhanced School Mental Health Program (eSMHP) Sponsors:   Human Development Research Foundation, Pakistan;   University of Liverpool;   University of Washington;   Pakistan Minis...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Healthy Volunteers Intervention:   Drug: [14C]-CTP-543 Sponsors:   Concert Pharmaceuticals;   Celerion Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We describe here a case of progressive childhood-onset cerebellar ataxia with vertical supra nuclear gaze palsy with no family history and a normal magnetic resonance imaging (MRI) of brain. The clinical exome sequencing in this patient showed a homozygous mutation in SQSTM1. This case highlights the importance of next-generation sequencing in the diagnosis of inherited ataxia syndromes. SQSTM1 mutation should be considered in the differential diagnosis in a patient with both cerebellar ataxia and ophthalmological manifestations. PMID: 31525130 [PubMed - as supplied by publisher]
Source: Ophthalmic Genetics - Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
A person ’s working memory—which helps one manage complex tasks and maintain attention when faced with distractions—is believed to be a critical element of safe driving. Astudy inJAMA Network Open has found that adolescents who were involved in a motor vehicle accident had slower development of their working memory than adolescents who were not involved in a crash.“Monitoring WM [working memory] development across adolescence as part of routine assessment could help to identify at-risk drivers, as well as opportunities for intervention,” wrote Elizabeth A. Walshe, Ph.D., of the Annenberg Publi...
Source: Psychiatr News - Category: Psychiatry Tags: adolescents car crashes development driving Elizabeth Walshe impulsivity IQ JAMA Network Open working memory Source Type: research
Condition:   ADHD Predominantly Inattentive Type Interventions:   Behavioral: Cognitive-behavioral therapy (Hesslinger protocol);   Behavioral: Cognitive-behavioral therapy (CADDI protocol) Sponsor:   Karolinska Institutet Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward. PMID: 31165428 [PubMed - as supplied by publisher]
Source: Cerebellum - Category: Neuroscience Authors: Tags: Cerebellum Source Type: research
We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward.
Source: The Cerebellum - Category: Neurology Source Type: research
ConclusionIt is important to keep in mind that in clinical course of celiac disease different neurological manifestations may be reported.ContextoVárias doenças neurológicas têm sido amplamente descritas em pacientes com doença celíaca.ObjetivoO objetivo deste estudo foi determinar a incidência de diferentes manifestações neurológicas em crianças com doença celíaca em acompanhamento no momento do diagnóstico e discutir essas manifestações à luz da literatura recente.MétodosEste estudo seccional transv...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
Conclusion Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10 R...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research
Conclusions: We identified a de novo KCND3 mutation causing the most marked change in Kv4.3’s channel properties reported so far, which correlated with a severe and unique spinocerebellar ataxia (SCA) type 19/22 disease phenotype.
Source: BioMed Central - Category: Journals (General) Authors: Source Type: research
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