Chemical constituents from the aerial parts of < em > Rubia cordifolia < /em > L. with their NO inhibitory activity

Nat Prod Res. 2023 Mar 27:1-8. doi: 10.1080/14786419.2023.2192491. Online ahead of print.ABSTRACTA new naphthoquinone derivative (1) together with twenty-three known compounds (2-24), were isolated from the aerial parts of Rubia cordifolia L. Their structures were elucidated on the basis of NMR and HR-ESIMS data. Compounds 1-13 were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 2-6 exhibited significant inhibitory activities with IC50 values of 21.37, 13.81, 24.56, 20.32, and 30.08 μmol·L-1, respectively.PMID:36971058 | DOI:10.1080/14786419.2023.2192491

Source: Natural Product Research - March 27, 2023 Category: Biochemistry Authors: Hong Zhang Wen-Tao Fang Yan Li Qing-Hua Kong Cheng-Wu Fang Han Luo Shou-Jin Liu Source Type: research