Incipient renal transplant dysfunction associates with tubular syndecan-1 expression and shedding.

Incipient renal transplant dysfunction associates with tubular syndecan-1 expression and shedding. Am J Physiol Renal Physiol. 2015 May 13;:ajprenal.00127.2015 Authors: Adepu S, Rosman CW, Dam W, van Dijk MC, Navis G, van Goor H, Bakker SJ, van den Born J Abstract Syndecan-1 is a transmembrane heparan sulfate proteoglycan involved in regenerative growth and cellular adhesion. We hypothesize that induction of tubular syndecan-1 is a repair response to incipient renal damage in apparently stable, uncomplicated renal transplant recipients. We quantified tubular syndecan-1 in unselected renal protocol biopsies taken one year after transplantation. Spearman rank correlation analysis revealed an inverse correlation between tubular syndecan-1 expression and creatinine clearance at time of biopsy (r = -0.483; p<0.03). In a larger panel of protocol and indication biopsies from renal transplant recipients, tubular syndecan-1 correlated with tubular proliferation marker Ki67 (r=0.518, p<0.0001). In a rat renal transplantation model, two months after transplantation, mRNA expression of syndecan-1 and its major sheddase ADAM-17 were upregulated (both p<0.03). Since shed syndecan-1 might end up in the circulation, in a stable cross-sectional human renal transplant population (n=510) we measured plasma syndecan-1. By multivariate regression analysis we showed robust independent associations of plasma syndecan-1 with renal (plasma creatinin...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research