Fusion peptide is superior to co-expressing subunits for arming oncolytic herpes virus with interleukin 12

CONCLUSIONS: The results implicate that a fusion-type expression of IL-12 is a method superior to co-expression of separate subunits, due to higher production of functional IL-12 molecules. This study led to the creation of triple-mutated oncolytic HSV-1 armed with human IL-12 currently used in phase 1/2 trial for malignant melanoma.PMID:36966232 | PMC:PMC10039936 | DOI:10.1038/s43856-023-00270-4

Source: Herpes - March 25, 2023 Category: Infectious Diseases Authors: Hiroshi Fukuhara Yuzuri Tsurumaki Sato Jiangang Hou Miwako Iwai Tomoki Todo Source Type: research